Τίτλος:
Epoetin alfa reduces blood transfusion requirements in patients with intertrochanteric fracture
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
Purpose: The purpose of this study is to identify the potential benefits or complications from the use of epoetin alfa in patients with intertrochanteric fracture. Materials and Methods: Seventy-nine patients who sustained an intertrochanteric fracture were divided into 2 groups. One group received 10 daily doses of 20 000 IU of epoetin alfa beginning from the day of trauma, whereas the control group received placebo. Results: We found a statistically significant difference in the required units of allogenic blood used between the 2 groups (P = .034). The group that received epoetin alfa also showed an elevation of hematocrit and hemoglobin values, which was statistically significant at the seventh postoperative day (P = .019 and .015, respectively) compared to the control group. No complications were evident during our study. Conclusions: Patients with intertrochanteric fractures seem to benefit from the use of epoetin alfa because it is safe and reduces the need for blood transfusions. © 2010 Elsevier Inc.
Συγγραφείς:
Kateros, K.
Sakellariou, V.I.
Sofianos, I.P.
Papagelopoulos, P.J.
Περιοδικό:
Journal of Critical Care
Λέξεις-κλειδιά:
hemoglobin; iron; paracetamol; recombinant erythropoietin, aged; anemia; article; blood transfusion; chill; controlled study; diarrhea; drug efficacy; drug fever; drug induced disease; drug induced headache; drug safety; female; femur intertrochanteric fracture; fever; flushing; hematocrit; hemoglobin blood level; human; injection site contusion; lips tingling; major clinical study; male; perioperative complication; postoperative period; preoperative evaluation; side effect; skin disease; treatment response; vomiting, Aged; Aged, 80 and over; Blood Transfusion; Epoetin Alfa; Female; Follow-Up Studies; Hematinics; Hematocrit; Hemoglobins; Hip Fractures; Humans; Male; Postoperative Period; Treatment Outcome
DOI:
10.1016/j.jcrc.2009.04.008
