Τίτλος:
Predictive value of increased nuchal translucency as a screening test for the detection of fetal chromosomal abnormalities
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
Objective.The study aimed to estimate the incidence of increased nuchal translucency in the first trimester ultrasound scan results cut-off limit 2.5 mm and to evaluate the predictive value of increased nuchal translucency as a screening test for the detection of fetal chromosomal abnormalities. Methods.We used the ultrasound scan results of nuchal translucency evaluation and the results of chromosomal analysis of the invasive prenatal control performed as a result of increased nuchal translucency. Results.We collected 2183 nuchal translucency ultrasound scans in which we detected 21 embryos with a pathologic value 0.96. We collected the data of 168 cases of invasive prenatal control due to increased nuchal translucency from which 122 cases were found. A total of 122 cases of pregnant women undergone an invasive prenatal diagnostic method due to increased nuchal translucency, of which 11 fetuses were found with trisomy 21 Down syndrome 9, 3 fetuses with trisomy 13 Patau syndrome 2.45, 3 fetuses with monosomy 45XO Turner syndrome 2.45 and 1 fetus with translocation 0.8. Conclusions.The positive predictive value of the increased fetal nuchal translucency as a screening test for the detection of fetal chromosomal abnormalities based on the results of the chromosomal-genetic analysis of the invasive prenatal diagnostic procedures is 14.8. © 2009 Informa UK Ltd All rights reserved.
Συγγραφείς:
Alexioy, E.
Trakakis, E.
Kassanos, D.
Farmakidis, G.
Kondylios, A.
Laggas, D.
Salamalekis, E.
Florentin, L.
Kanavakis, E.
Basios, G.
Trompoukis, P.
Georgiadoy, L.
Panagiotopoulos, T.
Περιοδικό:
Journal of Maternal-Fetal and Neonatal Medicine
Λέξεις-κλειδιά:
adolescent; adult; amniocentesis; article; chorion villus sampling; chromosome aberration; chromosome translocation; clinical article; Down syndrome; embryo; female; fetus; human; karyotype 45,X; maternal age; nuchal translucency measurement; Patau syndrome; prenatal screening; priority journal; screening test; trisomy 13; trisomy 21; Turner syndrome, Adolescent; Adult; Amniocentesis; Chromosome Aberrations; Cytogenetic Analysis; Down Syndrome; Female; Fetal Diseases; Gonadal Dysgenesis; Humans; Maternal Age; Middle Aged; Nuchal Translucency Measurement; Predictive Value of Tests; Pregnancy; Pregnancy Trimester, First; Young Adult
DOI:
10.1080/14767050902994572
