Τίτλος:
Rapamycin for Focal Segmental Glomerulosclerosis: A Report of 3 Cases
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
Corticosteroids and/or cyclosporine constitute the present therapeutic approach for patients with focal segmental glomerulosclerosis (FSGS). The high incidence of side effects for the former and risk of nephrotoxicity combined with the high relapse rate after discontinuation for the latter render their use problematic. Results concerning the role of rapamycin in the treatment of patients with FSGS are conflicting. We describe results for 3 patients treated with a combination of low-dose steroids and rapamycin for FSGS, focusing on the importance of maintaining low drug (rapamycin) levels by using a twice-daily regimen. © 2009 National Kidney Foundation, Inc.
Συγγραφείς:
Tsagalis, G.
Psimenou, E.
Iliadis, A.
Nakopoulou, L.
Laggouranis, A.
Περιοδικό:
American Journal of Kidney Diseases
Λέξεις-κλειδιά:
atorvastatin; fish oil; methylprednisolone; omega 3 fatty acid; rapamycin; steroid, adult; anamnesis; article; case report; clinical feature; disease course; drug blood level; female; focal glomerulosclerosis; follow up; human; human tissue; hyperlipidemia; kidney biopsy; low drug dose; male; physical examination; proteinuria; treatment outcome, Adult; Drug Therapy, Combination; Female; Glomerulosclerosis, Focal Segmental; Glucocorticoids; Humans; Immunosuppressive Agents; Male; Methylprednisolone; Middle Aged; Sirolimus
DOI:
10.1053/j.ajkd.2008.12.024
