Τίτλος:
Differential associations of renal function with coronary and peripheral atherosclerosis
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
Background: The aim of this study was to examine the impact of renal dysfunction on both coronary and peripheral atherosclerosis in patients with coronary artery disease (CAD) without severe renal impairment. Methods: One hundred and eighty-seven consecutive patients referred for elective coronary angiography were enrolled. Mean IMT and the presence of plaques were measured in the carotid and femoral arteries prior to angiography as markers of subclinical peripheral atherosclerosis. The severity of CAD was evaluated by the Gensini score. Glomerular filtration rate (GFR) was estimated by the MDRD formula. Results: Significant CAD (> 50% stenosis) was identified in 139 patients. GFR independently correlated with the presence and severity of CAD with incremental value over that of IMT. Renal function was significantly but not independently correlated with carotid IMT in CAD patients. Femoral IMT and the presence of plaques did not show any significant correlations with GFR in patients with or without CAD. Conclusions: Renal function is an important predictor of the presence and severity of angiographic CAD in patients without severe renal impairment with incremental value over traditional risk factors for CAD and IMT. The contrasting weak or no associations of GFR with IMT and the presence of plaques suggest that renal dysfunction may exert differential effects on the development of coronary and peripheral atherosclerosis. © 2008 Elsevier Ireland Ltd. All rights reserved.
Συγγραφείς:
Stamatelopoulos, K.S.
Lekakis, J.P.
Tseke, P.
Ikonomidis, I.
Kollias, G.E.
Alevizaki, M.
Kanakakis, I.
Voidonikola, P.
Zakopoulos, N.
Papamichael, C.M.
Περιοδικό:
International Journal of Cardiology
Λέξεις-κλειδιά:
adult; aged; angiocardiography; artery intima; artery intima proliferation; artery media; article; atherosclerotic cardiovascular disease; atherosclerotic plaque; calculation; coronary artery atherosclerosis; correlation analysis; disease association; disease severity; female; femoral artery; Gensini Score; glomerulus filtration rate; human; kidney function; major clinical study; male; Modification of Diet in Renal Disease formula; prediction; priority journal; scoring system; thickness, Aged; Carotid Artery Diseases; Coronary Angiography; Coronary Artery Disease; Female; Femoral Artery; Glomerular Filtration Rate; Humans; Kidney; Kidney Failure; Male; Middle Aged; Predictive Value of Tests; Risk Factors; Severity of Illness Index
DOI:
10.1016/j.ijcard.2008.03.041
