Τίτλος:
Peroxisome proliferator-activated receptor gamma expression in urothelial carcinomas of the bladder: Association with differentiation, proliferation and clinical outcome
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
Aims: Peroxisome proliferator-activated receptor γ (PPARγ) is a ligand-activated transcriptional factor that regulates the transcription of various target genes. Our purpose is to investigate the clinicopathologic and prognostic significance of PPARγ expression in human urothelial bladder cancer (BUC). Methods: Immunohistochemistry was applied in 117 paraffin-embedded specimens of human BUC to detect the proteins PPARγ and Ki67. The image analysis method was used for the evaluation of the immunohistochemical staining. Results: PPARγ protein was localized in the nuclei of the malignant cells. Its expression was inversely associated with the stage of BUCs (p < 0.001), tumor grade (p = 0.007) and the expression of the proliferation marker Ki67 (p = 0.015) while it was found to exert a favorable effect on patients' overall survival (p = 0.001). Conclusion: The findings of the present study suggest that in BUC, PPARγ expression can identify patients with a better prognosis who suffer from more differentiated, non-invasive tumors, of a low proliferative potential. © 2008 Elsevier Ltd. All rights reserved.
Συγγραφείς:
Mylona, E.
Giannopoulou, I.
Diamantopoulou, K.
Bakarakos, P.
Nomikos, A.
Zervas, A.
Nakopoulou, L.
Περιοδικό:
European Journal of Surgical Oncology
Λέξεις-κλειδιά:
Ki 67 antigen; peroxisome proliferator activated receptor gamma, adult; aged; article; bladder carcinoma; cell nucleus; female; human; human tissue; immunohistochemistry; male; priority journal; prognosis; protein expression; protein localization; urothelial bladder cancer, Adult; Aged; Aged, 80 and over; Carcinoma, Transitional Cell; Cell Differentiation; Cell Proliferation; Disease Progression; Female; Follow-Up Studies; Humans; Immunohistochemistry; Male; Middle Aged; Neoplasm Staging; PPAR gamma; Prognosis; Time Factors; Tumor Markers, Biological; Urinary Bladder Neoplasms; Urothelium
DOI:
10.1016/j.ejso.2008.04.003
