Τίτλος:
Endothelin system and atrial fibrillation post-cardiac surgery
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
Objective: We investigated the relation between the endothelin system and atrial fibrillation. Background: Endothelin has been implicated in the pathophysiology of atrial fibrillation, but the exact role of A- and B-receptors is unknown. Methods: We obtained right atrial biopsies from patients in sinus rhythm and preserved left ventricular function, undergoing off-pump coronary artery bypass grafting. The expression of endothelin, A- and B-receptors was measured using real time reverse-transcribed polymerase chain reaction. Results: We studied 52 patients (45 male, mean age 66±1 years, mean ejection fraction 52±1%). During a 5-day post-operative period, persistent atrial fibrillation occurred in 15 patients (28.8%). Endothelin mRNA expression was comparable in patients who subsequently developed atrial fibrillation and in those maintaining sinus rhythm. However, the former group displayed down-regulation of endothelin A- (by approximately 60%, p=0.0059) and of B-receptors (by approximately 40%, p=0.0084). The decreased endothelin A-receptor expression could predict atrial fibrillation occurrence (Wilks λ=0.86, F=6.16, p=0.017). Conclusion: Decreased endothelin A- and B-receptor expression is associated with atrial fibrillation after bypass surgery. © 2008 Springer Science+Business Media, LLC.
Συγγραφείς:
Kolettis, T.M.
Kyriakides, Z.S.
Zygalaki, E.
Kyrzopoulos, S.
Kaklamanis, L.
Nikolaou, N.
Lianidou, E.S.
Kremastinos, D.Th.
Περιοδικό:
Journal of Interventional Cardiac Electrophysiology
Λέξεις-κλειδιά:
endothelin; endothelin A receptor; endothelin B receptor; messenger RNA, aged; article; comparative study; controlled study; down regulation; female; heart atrium fibrillation; heart ejection fraction; heart left ventricle function; heart muscle biopsy; heart surgery; human; human tissue; major clinical study; male; off pump coronary surgery; pathophysiology; postoperative care; priority journal; real time polymerase chain reaction; reverse transcription polymerase chain reaction; sinus rhythm; statistical significance, Aged; Atrial Fibrillation; Biopsy; Chi-Square Distribution; Coronary Artery Bypass, Off-Pump; Endothelins; Female; Humans; Male; Predictive Value of Tests; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; ROC Curve; Sensitivity and Specificity; Statistics, Nonparametric
DOI:
10.1007/s10840-008-9206-5
