Τίτλος:
Aging and glycoxidant stress
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
Aging and related diseases are accompanied by increased Oxidative Stress (OS) and accumulation of Advanced Glycation End products (AGEs). One important component of AGEs accumulation with aging appears to be the sustained exposure to dietary AGE (dAGEs), which contributes to overloading of anti-AGE receptors and depletion of anti-oxidant reserves. In this review, we present experimental animal and human data which support this postulation. Lowering the content of AGEs in the normal diet significantly prevents AGEs accumulation and the increased OS caused by aging and also extends lifespan in mice. In humans, short-term trials indicate that a Low AGEs diet reduces oxidant burden and inflammatory markers. Long-term studies are in progress and will help establish definitive causality between age-related disease states and modern dietary practices in Western societies.
Συγγραφείς:
Peppa, M.
Uribarri, J.
Vlassara, H.
Περιοδικό:
Vitamins and Hormones
Εκδότης:
Hellenic Endocrine Society
Λέξεις-κλειδιά:
advanced glycation end product; antioxidant; advanced glycosylation end product receptor; advanced glycosylation end-product receptor; immunoglobulin receptor, aging; causal attribution; diet; glycation; glycoxidant stress; human; inflammation; lifespan; nonhuman; oxidative stress; review; aged; animal; metabolism; physiology, Aged; Aging; Animals; Glycosylation End Products, Advanced; Humans; Oxidative Stress; Receptors, Immunologic
