Τίτλος:
The expression of C-myc, tenascin and HER-2/neu in uterine sarcomas and its relation to clinical outcome
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
Introduction: The purpose of this study was to evaluate the expression of oncogenes C-myc, HER-2/neu and the extracellular matrix glucoprotein Tenascin in uterine sarcomas and its relation to clinical outcome (survival and recurrence rates). Patients or Methods: 36 patients with uterine sarcomas participated in the study, where 22 suffered from mixed mullerian tumors, 10 from leiomyosarcoma and 4 from other types. C-myc, Tenascin and HER-2/neu expression was evaluated in all 36 cases by the use of immunochistochemical procedures. Results: C-myc was positive in 23 out at 36 cases (64%), Tenascin in 15 out at 36 cases (42%), and HER/2-neu in 8 out at 36 cases (22%). Survival and recurrence rates were not found to differ significantly between positive or negative expression of all three substances of our study. Conclusion: In the 36 uterine sarcomas of the present study (22 mixed mullerian tumors, 10 leiomyosarcomas and 4 other types), expression of any of the 3 proteins investigated is not associated with increased/decreased survival or recurrence. © Georg Thieme Verlag KG Stuttgart.
Συγγραφείς:
Zafeiriou, S.
Papadimitriou, C.
Markaki, S.
Pavlou, B.
Voulgaris, Z.
Rodolakis, A.
Vlachos, G.
Diakomanolis, E.
Zervoudis, S.
Antsaklis, A.
Schindler, A.E.
Περιοδικό:
Tumor Diagnostik und Therapie
Λέξεις-κλειδιά:
epidermal growth factor receptor 2; Myc protein; tenascin, cancer recurrence; cancer survival; clinical article; controlled study; female; gene expression; human; immunohistochemistry; leiomyosarcoma; Muellerian duct; oncogene c myc; protein expression; review; uterus sarcoma
DOI:
10.1055/s-2007-963240
