Τίτλος:
Enterovirus-induced fulminant myocarditis and hemophagocytic syndrome
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
We report the case of a 17-year-old male who was admitted to the emergency department in cardiogenic shock and multiorgan failure due to fulminant myocarditis. The following days the patient developed anemia, thrombocytopenia, and hepatosplenomegaly. Bone marrow examination showed many mature histiocytes with active hemophagocytosis. Nested reverse transcriptase-PCR molecular analysis of blood samples and sequencing of the amplified alleles confirmed enteroviral infection. Our patient was treated with inotropic agents and immunoglobulin, and recovered completely. This is the first report that documents concomitant presentation of fulminant myocarditis and hemophagocytic syndrome due to enteroviral infection. © 2006 The British Infection Society.
Συγγραφείς:
Letsas, K.P.
Filippatos, G.S.
Delimpasi, S.
Spanakis, N.
Kounas, S.P.
Efremidis, M.
Tsakris, A.
Kardaras, F.
Περιοδικό:
Journal of Infection
Λέξεις-κλειδιά:
ceftriaxone; doxycycline; immunoglobulin; inotropic agent; meropenem; virus DNA; virus RNA, adolescent; allele; anemia; article; blood sampling; bone marrow examination; cardiogenic shock; case report; cell count; cell maturation; disease course; DNA sequence; echocardiography; electrocardiography; emergency ward; Enterovirus; Enterovirus infection; erythrophagocytosis; gene sequence; hemophagocytic syndrome; hepatosplenomegaly; histiocyte; hospital admission; human; laboratory test; male; multiple organ failure; reverse transcription polymerase chain reaction; RNA sequence; sequence analysis; thrombocytopenia; virus myocarditis, Adolescent; Bone Marrow Examination; Enterovirus; Enterovirus Infections; Humans; Lymphohistiocytosis, Hemophagocytic; Male; Myocarditis
DOI:
10.1016/j.jinf.2006.04.006
