Τίτλος:
High-dose misoprostol used in outpatient management of first trimester spontaneous abortion
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
Aim: The aim of this study was to evaluate the efficacy and tolerance of a high dose of vaginal misoprostol for outpatient medical management of missed abortion. Methods: Three doses of 400 μg misoprostol were administered intravaginally every 4 h daily, for a maximum period of 3 days, to 108 women with uneventful first trimester pregnancy failure. Results: A total of 98 women (90.7%) were managed successfully, with 74 (68.5%) of them within the first 24 h. The mean dose of misoprostol administered was 1,113.0 μg (range 400-3,600 μg), and the mean time required was 19.5 h (range 7-65 h). Only 6 out of 108 women (9.3%) required surgical intervention as the result of retained products of conception. The side effect profile was minimal. Conclusion: This protocol of 400 μg intravaginally misoprostol every 4 h as three daily doses for a maximum of 3 days, may offer an efficacious and safe alternative to the outpatient management of first-trimester missed abortion. © Springer-Verlag 2005.
Συγγραφείς:
Sifakis, S.
Angelakis, E.
Vardaki, E.
Fragouli, Y.
Koumantakis, E.
Περιοδικό:
Archives of Gynecology and Obstetrics
Λέξεις-κλειδιά:
misoprostol, adult; article; chill; conception; diarrhea; drug efficacy; drug induced headache; drug megadose; drug safety; drug tolerability; female; fever; first trimester pregnancy; human; infection; major clinical study; missed abortion; nausea; outpatient care; pregnancy disorder; spontaneous abortion; uterus bleeding; vomiting, Abortifacient Agents, Nonsteroidal; Abortion, Missed; Administration, Intravaginal; Adolescent; Adult; Dose-Response Relationship, Drug; Drug Administration Routes; Female; Humans; Misoprostol; Outpatients; Pregnancy; Pregnancy Trimester, First; Treatment Outcome
DOI:
10.1007/s00404-004-0697-8
