Τίτλος:
Synergia of a heparinoid and promethazine hydrochloride against liver cell necrosis
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
The effects of combined treatment with a heparinoid-sodium pentosan polysulfate - and an antihistamine-promethazine hydrochloride - against thioacetamide-induced rat liver injury were studied. Treatment by promethazine hydrochloride at 0 and 6 hrs by 2.5 and 1.25 mg per 100 g body weight or by 1.5 mg pentosan polysulfate did not afford a real protection against liver injury. The combined, however, of these two incompletely acting schedules treatment inhibited substantially the development of liver cellnecrosis up to 96 hrs. A synergic action of the above protective agents could be supposed. © 1974 Springer-Verlag.
Συγγραφείς:
Bartsokas, St.K.
Papacharalampous, N.X.
Papadimitriou, D.G.
Katapoti, Z.
Περιοδικό:
Research in Experimental Medicine
Λέξεις-κλειδιά:
antihistaminic agent; eosin; hematoxylin; heparinoid; pentosan polysulfate; promethazine; thioacetamide, dose liver function relation; drug administration; drug potentiation; drug toxicity; intoxication; liver; liver injury; liver necrosis; rat; theoretical study; therapy, Animal; Drug Synergism; Drug Therapy, Combination; Female; Heparinoids; Liver Cirrhosis, Experimental; Male; Promethazine
