Περίληψη:
Background. Accumulating epidemiological studies have shown that healthy
offspring of hypertensive patients exhibit some metabolic disturbances
such as hyperinsulinemia, insulin resistance, lipid disorders, elevated
plasma leptin levels and reduced insulin receptor number, features that
may be predictors of future cardiovascular events. The aim of this study
was to determine insulin, adiponectin and resistin plasma levels in
young healthy offspring of patients with essential hypertension, and to
compare the findings to those of young healthy offspring of healthy
normotensives matched for age, sex and body mass index (BMI). Methods.
Forty-six (24 male/22 female) healthy offspring of patients with
essential hypertension-positive family history (FH+), mean age 18 +/- 3
years and BMI 22.4 +/- 1.4 kg/m(2) (group A) and 50 (28 male/22 female)
healthy offspring of healthy normotensives-negative family history (FH-)
mean age 18 +/- 3.2 years and BMI 22.6 +/- 1.7 kg/m(2) (group B) were
studied. The two groups were matched for age, sex and BMI. Systolic and
diastolic blood pressure (SBP and DBP) measurements, resting heart rate
(HR), plasma insulin (RIA method), adiponectin and resistin plasma
levels (ELISA) were determined in the whole study population. Results.
Mean SBP, DBP and resting HR were significantly higher in group A
compared with group B (121 +/- 13 vs 110 +/- 10 mmHg, 78 +/- 6 vs 73 +/-
8 mmHg, 76 +/- 4 vs 72 +/- 6 beats/min,p < 0.01, p < 0.05 and p < 0.01
respectively). Insulin and resistin plasma levels were significantly
higher, while adiponectin levels were significantly lower. In group A
compared with group B (21 +/- 7 vs 15 +/- 6 pIU/ml, 10 +/- 5 vs 6 +/- 3
ng/ml, 20 +/- 5 vs 29 +/- 8 mu g/ml, p < 0.01, p < 0.01, p < 0.01,
respectively). Conclusion. Our findings suggest that increased SBP, DBP
and resting HR as well as increased insulin and resistin plasma levels
and decreased adiponectin plasma levels pre-exist in young healthy
offspring with positive family history for essential hypertension.
Further studies are needed to determine the clinical significance of
these observations in attempt to classify these young healthy
individuals for future cardiovascular risk.
Συγγραφείς:
Papadopoulos, D. P.
Makris, Th. K.
Perrea, D.
Papazachou, O.
and Daskalaki, M.
Sanidas, E.
Votteas, V.
