Τίτλος:
Non-gastric extra-nodal marginal zone lymphomas-a single centre
experience on 76 patients
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
In the present study, we assessed the clinical and pathological data of
76 patients with the diagnosis of non-gastric extranodal marginal zone
B-cell lymphoma. The most commonly affected sites were salivary glands,
skin, ocular adnexa, lung, intestine and Waldeyer’s ring. Ann Arbor
stage I disease was present in 39 patients (51%), stage II in 10 (13%)
and stage IV in 27 (36%). In 17 cases (21%), the lymphoma presented at
multiple mucosal sites. Lymph node and bone marrow involvement were
present in 21% and 16%, respectively. Most cases were in the low or
low-intermediate risk group. Treatment was heterogeneous and included
chlorambucil in 59% either alone or in combination with other agents.
Complete and partial remission was achieved in 79% and 7%,
respectively, with an overall response rate of 86%. The 5- and 10-year
overall survival and cause-specific survival rates were 94%, 82% and
95%, 91%, respectively. The 5- and 10-year progression free survival
was 56% and 41%, respectively. The only feature associated with
inferior outcome was disease localisation to the lung.
Συγγραφείς:
Kalpadakis, Christina
Pangalis, Gerassimos A.
Vassilakopoulos,
Theodoros P.
Kyrtsonis, Maria-Christina
Siakantaris, Marina P.
and Kontopidou, Flora N.
Korkolopoulou, Penelope
Bobotsis,
Panagia
Sahanas, Sotirios
Tzenou, Tatiana
Anagnostou,
Dimitra
Dimitriadou, Evangelia
Yiakoumis, Xanthi
Patsouris,
Evangelos
Roussou, Panagiota
Panayiotidis, Panayiotis and
Papadaki, Eleni
Angelopoulou, Maria K.
Περιοδικό:
Leukemia & Lymphoma
Εκδότης:
TAYLOR & FRANCIS LTD LONDON
Λέξεις-κλειδιά:
MALT; lymphoma; extranodal marginal zone lymphoma
DOI:
10.1080/10428190802510331
