Τίτλος:
In vitro activity of CAY-1, a saponin from Capsicum frutescens, against
Microsporum and Trichophyton species
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
Dermatomycoses are among the world’s most common diseases and their
incidence has increased over recent years, particularly in
immunosuppressed patients. In previous studies, the saponin CAY-1 from
cayenne pepper (Capsicum frutescens), has shown antifungal activities
against Candida albicans and Aspergillus spp. We therefore studied the
in vitro antifungal activity of CAY-1 against non-germinating conidia
and hyphae of clinical isolates of the dermatophytes Trichophyton
mentagrophytes, T. rubrum, T. tonsurans and Microsporum canis. We used a
microdilution method to assess the growth inhibitory activities of CAY-1
against conidia (CLSI document M38-A) and a colorimetric procedure (XTT
method) to investigate the metabolic inhibitory activity of CAY-1
against hyphae. The minimal inhibitory concentrations (complete visual
growth inhibition) of CAY-1 against non-germinating conidia ranged from
10-20 g/ml for all dermatophyte isolates included in this investigation.
In addition, we found 90% inhibition of hyphal metabolic activity of
these same isolates with 10-20 g/ml of CAY-1. Results indicate that
CAY-1 merits further investigation as a potential agent for the
treatment of dermatomycoses.
Συγγραφείς:
Stergiopoulou, Theodouli
De Lucca, Anthony J.
Meletiadis, Joseph
and Sein, Tin
Boue, Stephen M.
Schaufele, Robert
Roilides,
Emmanuel
Ghannoum, Mahmoud
Walsh, Thomas J.
Περιοδικό:
Medical Mycology
Εκδότης:
LIBRAPHARM/INFORMA HEALTHCARE
Λέξεις-κλειδιά:
dermatophytes; Capsicum frutenses; saponin
DOI:
10.1080/13693780802089831
