Τίτλος:
Effect of Greek Raisins (Vitis Vinifera L.) From Different Origins on
Gastric Cancer Cell Growth
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
Currants and Sultanas (Vitis vinifera L.) are dried vine products
produced in Greece and used broadly in the Mediterranean diet. We aimed
to investigate the gastric cancer preventive activity of methanol
extracts obtained from currants from three different origins in Greece
(Vostizza, Nemea, and Messinia) as well as methanol extracts obtained
from Sultanas cultivated in the island of Crete as to inhibition of cell
proliferation, induction of apoptosis, and inhibition of inflammation.
All extracts from 500 mu g dried raisins studied suppressed cell
proliferation, significantly those obtained from Sultanas from Crete and
currants from Nemea. Flow cytometric analysis of Annexin-V labeled cells
indicated that Cretan Sultana, Nemea, and Messinia currants at 500 mu g
dried product/ml medium significantly induced cell death. All extracts
from 500 mu g dried raisins statistically decreased protein and mRNA
levels of ICAM-1 in TNF-alpha stimulated cells. Measurement of IL-8
protein levels and quantification for IL-8 mRNA showed no significant
decrease. These results indicate that the methanol extracts from
currants, rich in phenolic compounds, exhibit cancer preventive efficacy
by limiting cell proliferation, inducing cell death, and suppressing
ICAM-1 levels in AGS cells.
Συγγραφείς:
Kaliora, Andriana C.
Kountouri, Aggeliki M.
Karathanos, Vaios T.
and Koumbi, Lemonica
Papadopoulos, Nikolaos G.
Andrikopoulos,
Nikolaos K.
Περιοδικό:
NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL
Εκδότης:
ROUTLEDGE JOURNALS, TAYLOR & FRANCIS LTD
DOI:
10.1080/01635580802295776
