Περίληψη:
Purpose. To determine the inter-relation ships between cytokine levels
and physiological scores in predicting outcome in unselected, critically
ill patients. Methods. To this end, 127 patients (96 men), having a mean
+/- SD age of 45 +/- 20 years, with a wide range in admission diagnoses
(medical, surgical, and multiple trauma patients) were prospectively
investigated. Severity of critical illness and organ dysfunction were
graded by acute physiology and chronic health evaluation (APACHE 11) and
sequential organ failure assessment (SOFA) scores, respectively. Blood
samples were drawn on admission in the ICU to determine pro- and
anti-inflammatory cytokines, including tumor necrosis factor
(TNF)-alpha, interleukin (IL)-6, IL-8, and IL-10. The main outcome
measure was 28-day mortality. Results. Overall.. 88 patients survived
and 39 patients died. Univariate logistic regression analysis showed
that SOFA, APACHE 11, IL-8, IL-6, and IL-10 on admission in the ICU were
related to mortality. Multiple logistic regression analysis in the
entire cohort of critically ill patients revealed that SOFA (OR = 1.341,
p < 0.001) and IL-6 (OR = 1.075, p = 0.01) constituted independent
outcome predictors. receiver operator characteristics curve analysis
showed that SOFA, APACHE II, and IL-6 had the highest area under the
Curve values. IL-6 correlated with APACHE II (r(s) = 0.44, p < 0.0001)
and SOFA (rs = 0.40, p < 0.0001) scores. Conclusions. In mixed ICU
patients cytokine concentrations on admission in the ICU represent
independent outcome predictors in the presence of disease severity
scores. (c) 2007 Elsevier Ltd. All rights reserved.
Συγγραφείς:
Dirriopoulou, Ioanna
Orfanos, Stylianos
Kotanidou, Anastasia and
Livaditi, Olga
Glamarellos-Bourboulis, Evangellos
Athanasiou,
Chariklia
Korovesi, Ioanna
Sotiropoulou, Christina and
Kopterides, Petros
Ilias, Ioannis
Kanellakopoulou, Kyriaki and
Armaganidis, Apostolos
