Περίληψη:
Background: This study was designed to investigate the association of
the 894G>T polymorphism in the eNOS gene with risk of acute myocardial
infarction ( AMI), extent of coronary artery disease ( CAD) on coronary
angiography, and in-hospital mortality after AMI.
Methods: We studied 1602 consecutive patients who were enrolled in the
GEMIG study. The control group was comprised by 727 individuals, who
were randomly selected from the general adult population.
Results: The prevalence of the Asp298 variant of eNOS was not found to
be significantly and independently associated with risk of AMI ( RR =
1.08, 95% CI = 0.77-1.51, P = 0.663), extent of CAD on angiography ( OR
= 1.18, 95% CI = 0.63-2.23, P = 0.605) and in-hospital mortality ( RR =
1.08, 95% CI = 0.29-4.04, P = 0.908).
Conclusion: In contrast to previous reports, homozygosity for the Asp298
variant of the 894G>T polymorphism in the eNOS gene was not found to be
associated with risk of AMI, extent of CAD and in-hospital mortality
after AMI.
Συγγραφείς:
Andrikopoulos, George K.
Grammatopoulos, Dimitris K.
Tzeis,
Stylianos E.
Zervou, Sevasti I.
Richter, Dimitris J.
Zairis,
Michalis N.
Gialafos, Elias J.
Sakellariou, Dimitris C. and
Foussas, Stefanos G.
Manolis, Antonis S.
Stefanadis,
Christodoulos I.
Toutouzas, Pavlos K.
Hillhouse, Edward W. and
GEMIG Study Investigators
