Περίληψη:
OBJECTIVES
To determine the relationship between androgens, lower urinary tract
symptoms (LUTS) and urodynamic variables of bladder outlet obstruction
(BOO) in patients with LUTS/benign prostatic hyperplasia (BPH), as
androgens are important in the pathogenesis of LUTS.
PATIENTS AND METHODS
Twenty-five men with symptomatic BPH were enrolled in the study and had
a complete urodynamic investigation, establishing BOO. Age,
prostate-specific antigen level, prostate volume and postvoid residual
volume were recorded and the International Prostate Symptom Score (IPSS)
was estimated. Detrusor pressure at maximum flow (P(det)Q(max)), at
urethral closure (PdetCl, the pressure at the end of urinary flow) and
maximum detrusor pressure (P-detmax) was recorded, while detrusor
overactivity (DO) was noted when present. Blood samples were collected
to measure total testosterone (T), and free T (FT) was calculated.
Patients were grouped according to FT levels as low (< 72 pg/mL) and
normal (FT >= 72 pg/mL).
RESULTS
Ten patients had a low FT level, with a mean (SD) of 54.3 (16.5) pg/mL,
and 15 a normal level of FT, of 90.5 (11) pg/mL. FT was negatively
correlated with PdetCl, and P(det)Q(max); the mean PdetCl and
P(det)Q(max) differed significantly between patients with low and normal
FT levels. Fourteen patients had DO and they had significantly lower
levels of FT than those with no DO. All patients with a FT level of < 60
pg/mL had DO, and the presence of instability differed significantly
from the rest of the group.
CONCLUSIONS
Low T levels in clinical BOO correlated negatively with PdetCl and
P(det)Q(max), while promoting DO. Androgen seems to have an ameliorating
role in lower urinary tract function.
Συγγραφείς:
Koritsiadis, George
Stravodimos, Konstantinos
Mitropoulos,
Dionisios
Doumanis, Grigorios
Fokitis, Ioannis
Koritsiadis,
Sotirios
Constantinides, Constantinos
