Τίτλος:
Greek hyperinsulinemic women, with or without polycystic ovary syndrome,
display altered inositols metabolism
Περίληψη:
BACKGROUND: We have shown that American women with polycystic ovary
syndrome (PCOS) have decreased glucose-stimulated release of a putative
mediator of insulin action, D-chiro-inositol (DCI)-containing
inositolphosphoglycan (DCI-IPG), and increased urinary clearance of DCI
(uCl(DCI)), which was associated with hyperinsulinemia. METHODS: DCI
levels and the release of insulin and DCI-IPG during an oral glucose
tolerance test (AUCs) were assessed in 27 Greek PCOS and 10 normal Greek
women. RESULTS: PCOS women were heavier than controls (BMI = 28.4 versus
23.7 kg/m(2), P = 0.05) with higher waist-to-hip ratios (WHR = 0.78
versus 0.71, P = 0.009) and increased free testosterone (P = 0.048) and
AUC(insulin) (P = 0.04). In PCOS women, incremental AUC(DCI-IPG) was
significantly decreased by 59% (2158 versus 5276%.min, P = 0.01), even
after correction for BMI and WHR. Finally, increased uCl(DCI) (r = 0.35,
P = 0.04) and decreased AUC(DCI-IPG) (r = 0.46, P = 0.004) were
significantly associated with hyperinsulinemia in all women together,
even after correction for BMI and WHR (Ps = 0.02 and 0.007), and
regardless of PCOS status. CONCLUSION: Greek women, with or without
PCOS, display increased uCl(DCI) and decreased AUC(DCI-IPG) in
association with higher insulin levels but independent of adiposity.
Increased clearance of inositols might reduce tissue availability of DCI
and decrease the release of DCI-IPG mediator, which could contribute to
insulin resistance and compensatory hyperinsulinemia in Greek women, as
previously described in American women.
Συγγραφείς:
Baillargeon, Jean-Patrice
Nestler, John E.
Ostlund, Richard E.
and Apridonidze, Teimuraz
Diamanti-Kandarakis, Evanthia
