Περίληψη:
Flavonoids belong to a vast group of polyphenols widely distributed in
all foods of plant origin. Because of their antioxidant, antimutagenic
and antiproliferative properties, they have been hypothesized to
contribute to the favorable effects of fruit and vegetables against
cancer. The aim of this study is to investigate the relation of 6
classes of flavonoids (flavan-3-ols, flavanones, flavonols, flavones,
anthocyanidins and isoflavones) with ovarian cancer risk, using data
from a multicentric case-control study conducted in Italy between 1992
and 1999. The study included 1,031 cases with incident, histologically
confirmed epithelial ovarian cancer and 2,411 controls admitted for
acute, nonneoplastic conditions to major hospitals in the same catchment
areas. In logistic regression models including study center, education,
year of interview, parity, oral contraceptive use and family history of
ovarian or breast cancer or both, an inverse relation with significant
trend in risk was found between ovarian cancer and flavonols [odds
ratio (OR), 0.63; 95% confidence intervals (CI) 0.47-0.84] as well as
isoflavones (OR, 0.51; 95% CI, 0.37-0.69), comparing the highest versus
the lowest quintile. Further adjustment for fruit and vegetable intake
did not modify these associations, suggesting that isoflavones and
flavonols may have a distinct role in explaining the effect of fruit and
vegetable against ovarian cancer. On the basis of our findings and the
relevant literature, we infer that isoflavones, and perhaps flavonols,
may have favorable effects with respect to ovarian cancer risk. (c) 2008
Wiley-Liss, Inc.
Συγγραφείς:
Rossi, Marta
Negri, Eva
Lagiou, Pagona
Talamini, Renato and
Dal Maso, Luigino
Montella, Maurizio
Franceschi, Silvia
La
Vecchia, Carlo
