Τίτλος:
In vivo aortic valve thermal heterogeneity in patients with nonrheumatic
aortic valve stenosis
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
Objectives We investigated in vivo in aortic valve stenosis (AVS)
whether there is: 1) thermal heterogeneity within the valve leaflets; 2)
temperature difference between the leaflets and the ascending aortic
wall; and 3) a possible correlation between heat production,
inflammation, and neoangiogenesis.
Background Histological studies have demonstrated a potential role of
inflammation and neoangiogenesis in AVS.
Methods We examined 96 leaflets scheduled for aortic valve replacement.
Twenty-five patients had AVS, and 7 had aortic valve insufficiency
(AVI). Temperature measurements were performed right before hypothermic
cardioplegia. Temperature difference (Delta T) was assigned as the mean
temperature of each leaflet minus the temperature of the aortic wall.
Histological, immunohistological analysis, and vascular endothelial
growth factor (VEGF) immunoreactivity was performed.
Results Significant thermal heterogeneity was recorded within the
leaflets of AVS, compared with AVI (1.52 +/- 1.35 degrees C vs. 0.13 +/-
0.11 degrees C, p < 0.01). In AVS Delta T was greater in all leaflets
compared with the AVI group (p < 0.01). Leaflets of AVS had increased
inflammatory cell infiltration, calcium deposit, and anti-VEGF
expression compared with AVI (p < 0.01).
Conclusions Thermal heterogeneity is increased in AVS and correlates
with inflammatory mononuclear cell infiltration, expression of
pro-inflammatory cytokines and neoangiogenic factors.
Συγγραφείς:
Toutouzas, Konstantinos
Drakopoulou, Maria
Synetos, Andreas and
Tsiamis, Eleftherios
Agrogiannis, George
Kavantzas, Nikolaos and
Patsouris, Eustratios
Iliopoulos, Dimitris
Theodoropoulos,
Stergios
Yacoub, Magdi
Stefanadis, Christodoulos
Περιοδικό:
Journal of the American College of Cardiology
Εκδότης:
EXCERPTA MEDICA INC-ELSEVIER SCIENCE INC
Λέξεις-κλειδιά:
aortic valve; inflammation thermography
DOI:
10.1016/j.jacc.2008.04.057
