Τίτλος:
HIV-positive patients treated with protease inhibitors have vascular
changes resembling those observed in atherosclerotic cardiovascular
disease
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
A metabolic syndrome associated with atherosclerosis and cardiovascular
disease has been described in HIV-positive individuals. In the present
study we investigated whether HIV-positive individuals and CAD (coronary
artery disease) patients have similarities in their vascular function
and structure. In a case-control study, we compared measurements of
carotid artery IMT (intima-media thickness) and brachial artery FMD
(flow-mediated vasodilation) in HIV-positive individuals with age- and
sex-matched controls with similar risk factors and patients with
established CAD. Seventy-one HIV patients, age 42 +/- 13.9 years (91 %
male), were compared with 29 CAD patients and 25 controls. HIV patients
had higher IMT than controls and similar IMT to CAD patients (0.64 +/-
0.2 compared with 0.55 +/- 0.05 and 0.66 +/- 0.08 mm respectively; F =
4.2, P = 0.01). Patients taking protease inhibitors had higher IMT (0.69
+/- 0.2 compared with 0.57 +/- 0.15 mm; P = 0.01), blood pressure,
cholesterol and triacylglycerols than those not taking protease
inhibtors (P < 0.05). In multiple regression analyses, increasing blood
pressure (beta: 0.37, P = 0.001), glucose (beta: 0.26, P = 0.016),
cholesterol (beta: 0.24, P = 0.033), duration of HIV disease (beta:
0.33, P = 0.008) and use of protease inhibitors (beta: 0.27, P = 0.04)
were the most important determinants of IMT respectively. FMD was
associated only with triacylglycerol measurements. Patients with HIV
present arterial changes resembling those found in patients with
atherosclerotic cardiovascular disease. These vascular changes are
closely related to protease-inhibitor-induced changes of metabolic
parameters. Thus intensive treatment of these metabolic parameters might
retard atherosclerosis in HIV patients.
Συγγραφείς:
Lekakis, John
Tsiodras, Sotirios
Ikonomidis, Ignatios and
Palios, John
Poulakou, Garyfalia
Rallidis, Loukianos and
Antoniadou, Anastasia
Panagopoulos, Periklis
Papadopoulos,
Antonios
Giamarellou, Helen
Kremastinos, Dimitrios T.
Περιοδικό:
Clinical Science
Εκδότης:
PORTLAND PRESS LTD
Λέξεις-κλειδιά:
coronary artery disease; endothelial function; flow-mediated
vasodilation (FMD); HIV; highly active antiretroviral therapy (HAART);
intima-media thickness
