Τίτλος:
The significance of leptin, adiponectin, and resistin serum levels in
non-small cell lung cancer (NSCLC)
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
Adipose tissue secretes adipokines with proinflammatory and
anti-inflammatory properties. Our aim was to assess the role of adipose
tissue in generalized inflammatory state of advanced NSCLC patients and
the possible use of leptin, adiponectin and resistin as diagnostic and
prognostic markers. Correlation of adipose tissue with weight loss in
advanced NSCLC patients was also studied. Fasting serum levels of
leptin, adiponectin and resistin were determined in 101 advanced NSCLC
patients (76 without weight loss and 25 with weight loss) and 51 healthy
volunteers using commercially available ELISA. Adipokine serum Levels
were determined at diagnosis, at the end of first-line chemotherapy and
at the time of disease progression for those who responded to treatment.
Epidemiological, anthropometrical and laboratory data were assessed.
Serum leptin and adiponectin levels presented no differences. Serum
resistin levels were significantly increased in NSCLC patients after
adjustment for age, sex and BMI. Multivariate analysis showed that these
adipokines at diagnosis could not be used as predictive factors for
overall survival or time to progression. Only serum resistin levels were
associated with weight Loss. Despite no direct involvement of leptin and
adiponectin, resistin as a proinflammatory cytokine may play a role in
the pathogenesis of weight loss in NSCLC patients. (c) 2008 Elsevier
Ireland Ltd. All rights reserved.
Συγγραφείς:
Karapanagiotou, Eleni M.
Tsochatzis, Emmanouil A.
Dilana,
Kalliopi D.
Tourkantonis, Loannis
Gratsias, Ioannis
Syrigos,
Konstantinos N.
Περιοδικό:
Translational Lung Cancer Research
Εκδότης:
Elsevier Ireland Ltd
Λέξεις-κλειδιά:
leptin; adiponectin; resistin; non-small cell lung cancer; weight toss
DOI:
10.1016/j.lungcan.2008.01.018
