Τίτλος:
Increased plasma levels of 8-iso-PGF(2 alpha) and IL-6 in an elderly
population with depression
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
Oxidative damage and immune-inflammatory activation have been suggested
to play a role in depression. The purpose of the study was to
investigate possible associations and interactions of these
pathophysiological mechanisms in geriatric depression by determining the
levels of plasma 8-iso-prostaglandin F-2 alpha (8-iso-PGF(2 alpha)) and
interleukin-6 (IL-6) in elderly depressed individuals. Subjects over 60
years of age with depression and controls were randomly selected from a
population in the community after screening with the Geriatric
Depression Scale. Plasma concentrations of 8-iso-PGF2 alpha and IL-6
were measured in both groups. Depressed patients had significantly
higher mean (+/- S.D.) 8-iso-PGF2 alpha levels compared to healthy
controls (245.01 +/- 179.92 pg/ml vs 97.64 +/- 42.72 pg/ml,
respectively). Similarly, the same groups demonstrated significantly
elevated IL-6 levels compared with controls (58.73 +/- 39.90 pg/mI vs
15.41 +/- 9.27 pg/ml). This study indicates an association between
increased levels of plasma 8-iso-PGF2 alpha and IL-6 with depressive
symptomatology in elderly individuals and indicates the necessity for
further investigation, possibly within the framework of an integrated
involvement of oxidative damage and inflammation in the pathophysiology
of depression in the elderly. (c) 2007 Elsevier Ireland Ltd. All rights
reserved.
Συγγραφείς:
Dimopoulos, Nikolaos
Piperi, Christina
Psarra, Vassiliki and
Lea, Robert W.
Kalofoutis, Anastasios
Περιοδικό:
Psychiatry Research
Εκδότης:
Elsevier Ireland Ltd
Λέξεις-κλειδιά:
8-iso-PGF(2 alpha); IL-6; Depression; Elderly
DOI:
10.1016/j.psychres.2007.07.019
