Περίληψη:
Background: Epidemiologic studies have produced conflicting results with
respect to an association of dietary fat with breast cancer.
Objective: We aimed to investigate the association between fat
consumption and breast cancer.
Design: We prospectively investigated fat consumption in a large (n =
319 826), geographically and culturally heterogeneous cohort of European
women enrolled in the European Prospective Investigation into Cancer and
Nutrition who completed a dietary questionnaire. After a mean of 8.8 y
of follow-up, 7119 women developed breast cancer. Cox proportional
hazard models, stratified by age and center and adjusted for energy
intake and confounders, were used to estimate hazard ratios (HRs) for
breast cancer.
Results: An association between high saturated fat intake and greater
breast cancer risk was found [HR = 1.13 (95% CI: 1.00, 1.27; P for
trend = 0.038) for the highest quintile of saturated fat intake compared
with the lowest quintile: 1.02 (1.00, 1.04) for a 20% increase in
saturated fat consumption (continuous variable)]. No significant
association of breast cancer with total, monounsaturated, or
polyunsaturated fat was found, although trends were for a direct
association of risk with monounsaturated fat and an inverse association
with polyunsaturated fat. In menopausal women, the positive association
with saturated fat was confined to nonusers of hormone therapy at
baseline [1.21 (0.99, 1.48) for the highest quintile compared with the
lowest quintile; P for trend = 0.044; and 1.03 (1.00, 1.07) for a 20%
increase in saturated fat as a continuous variable].
Conclusions: Evidence indicates a weak positive association between
saturated fat intake and breast cancer risk. This association was more
pronounced for postmenopausal women who never used hormone therapy. Am J
Clin Nutr 2008; 88: 1304-12.
Συγγραφείς:
Sieri, Sabina
Krogh, Vittorio
Ferrari, Pietro
Berrino,
Franco
Pala, Valeria
Thiebaut, Anne C. M.
Tjonneland, Anne
and Olsen, Anja
Overvad, Kim
Jakobsen, Marianne Uhre and
Clavel-Chapelon, Francoise
Chajes, Veronique
Boutron-Ruault,
Marie-Christine
Kaaks, Rudolf
Linseisen, Jakob
Boeing,
Heiner
Noethlings, Ute
Trichopoulou, Antonia
Naska,
Androniki
Lagiou, Pagona
Panico, Salvatore
Palli, Domenico
and Vineis, Paolo
Tumino, Rosario
Lund, Eiliv
Kumle, Merethe
and Skeie, Guri
Gonzalez, Carlos A.
Ardanaz, Eva
Amiano,
Pilar
Tormo, Maria Jose
Martinez-Garcia, Carmen
Quiros, Jose
R.
Berglund, Goeran
Gullberg, Bo
Hallmans, Goeran and
Lenner, Per
Bueno-de-Mesquita, H. Bas
van Duijnhoven, Fraenzel
J. B.
Peeters, Petra H. M.
van Gils, Carla H.
Key, Timothy
J.
Crowe, Francesca L.
Bingham, Sheila
Khaw, Kay Tee and
Rinaldi, Sabina
Slimani, Nadia
Jenab, Mazda
Norat, Teresa
and Riboli, Elio
