Τίτλος:
Expression of integrin-linked kinase and its binding partners in
chondrosarcoma: Association with prognostic significance
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
Integrin-linked kinase (ILK) and its binding partners alpha-parvin,
beta-parvin, Mig-2 and Migfilin are important components of the
cell-matrix adhesions implicated in cell motility, growth, survival and
ultimately carcinogenesis. Herein, we investigated immunohistochemically
the expression of these molecules in cartilaginous neoplasms and
explored their involvement in chondrosarcoma pathobiology and behaviour.
Our analyses revealed that ILK, alpha-parvin, beta-parvin and Mig-2 are
expressed in the majority of chondrosarcomas but in a small proportion
of enchondromas, implying that these proteins might have a role in the
development and progression of chondrogenic neoplasms. moreover, our
findings highlight the possibilities that ILK might serve as biological
marker that could accurately predict a high-grade tumour and that Mig-2
may function as a promising prognostic indicator of high-risk patients.
(C) 2008 Elsevier Ltd. All rights reserved.
Συγγραφείς:
Papachristou, Dionysios J.
Gkretsi, Vassiliki
Rao, Uma N. M. and
Papachristou, Georgios I.
Papaefthymiou, Odysseas A.
Basdra,
Efthimia K.
Wu, Chuanyue
Papavassiliou, Athanasios G.
Περιοδικό:
EUROPEAN JOURNAL OF CANCER
Εκδότης:
Elsevier Sci Ltd, Exeter, United Kingdom
Λέξεις-κλειδιά:
Chondrosarcoma; ILK; Migfilin; Mig-2; Parvins; Prognosis; Survival
DOI:
10.1016/j.ejca.2008.07.021
