Τίτλος:
Regulation of Tumor-Stromal Fibroblast Interactions: Implications in
Anticancer Therapy
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
Recent advances in tumor biology have identified the stroma as an
important regulator of carcinogenesis and potentially a valuable
therapeutic target. While however the fact that by targeting the stromal
component of a tumor represents a potential therapeutic strategy has
been established, the knowledge for specific regulators for such
interactions remains poor. The latter is largely due to the fact that
appropriate methodological approaches that permit the screening for such
regulators are lacking. In the present review we will summarize some of
the literature underlining the central role of stromal factors, and
essentially that of the fibroblasts in tumorigenesis. Furthermore, we
will review the experimental evidence that suggest that by interfering
with tumor-stroma interactions may represent a therapeutic approach.
Finally, based on various experimental evidence and theoretical
considerations we will suggest a biological experimental system which
might facilitate the screening of such regulators.
Συγγραφείς:
Kiaris, Hippokratis
Trimis, George
Papavassiliou, Athanasios G.
Περιοδικό:
Current Medicinal Chemistry
Εκδότης:
BENTHAM SCIENCE PUBL LTD
Λέξεις-κλειδιά:
Stroma; fibroblasts; screening
DOI:
10.2174/092986708786848596
