Ερευνητικό υλικό ΕΚΠΑ

Diagnostic value of rapid urease test and urea breath test for
Helicobacter pylori detection in patients with Billroth II gastrectomy:
A prospective controlled trial

Αγγλικά

Aim. The aim of this work was to assess the reliability of rapid urease
test (RUT) and urea breath test (UBT) for detecting Helicobacter pylori
(H. pylori) in patients with Billroth II (BII) gastrectomy, using
histology as reference.
Methods. In this prospective controlled study, 31 consecutive patients
with 1311 gastrectomy and 73 controls who had an indication for
endoscopy were included. Their H. pylori status was assessed with
biopsies for histology, RUT and UBT. Histology served as the gold
standard. Only the biopsies from the gastric fundus were evaluated.
Specificity, sensitivity, positive and negative predictive value, degree
of agreement and k-statistics were used.
Results. RUT and UBT for detecting H. pylori in the control group had
excellent agreement [97%, kappa (k)=0.94 and 99%, k=0.97
respectively] with biopsies. In BII patients, RUT from fundic biopsies
had very good agreement (87%, k=0.74) compared to histology from fundic
biopsies, whereas the UBT was unreliable (agreement: 71%, k=0.41)
compared to histology.
Conclusion. The RUT from fundic biopsies in BII patients is a reliable
test for H. pylori detection, whereas the UBT is unreliable. (C) 2008
Editrice Gastroenterologica Italiana S.r.l. Published by Elsevier Ltd.
All rights reserved.

2009

Adamopoulos, A. B.
Stergiou, G. S.
Saklzlis, G. N.
Tiniakos,
D. G.
Nasothimiou, E. G.
Sioutis, D. K.
Achimastos, A. D.

Digestive and Liver Disease

EXCERPTA MEDICA INC-ELSEVIER SCIENCE INC

41

1

4-8

Billroth II; Helicobacter pylori; Kappa agreement; Rapid urease test;
Sensitivity; Specificity; Urea breath test

https://doi.org/10.1016/j.dld.2008.05.010

10.1016/j.dld.2008.05.010

https://pergamos.lib.uoa.gr/uoa/dl/object/3140945