Τίτλος:
Membranous nephritis associated with acquired cytomegalovirus infection
in a 19-month-old baby
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
Membranous nephritis (MN) is a rare form of glomerulonephritis in
childhood, with an incidence of 0.8 to 6.7% based on renal biopsy
specimens. Although the disease is considered to be idiopathic in the
majority of cases, especially in adults, MN has been associated with
various infectious agents, such as hepatitis. virus. The natural history
of MN in childhood remains unknown because of its rarity, and to the
best of our knowledge, no case of MN linked to cytomegalovirus (CMV)
infection in an immunocompetent child has been described to date. We
report here a 19-month-old female infant who presented with a
maculopapular rash, fever, and nephritic-nephrotic syndrome. Virology
tests for infectious diseases revealed a recent CMV infection. The renal
biopsy findings were compatible with MN, while PCR analysis of the renal
tissue specimen was positive for CMV DNA. Antiviral treatment (
ganciclovir) resulted in full remission of proteinuria and hematuria.
Two years after the initial diagnosis, the child remains well and
asymptomatic without clinical or laboratory evidence of the disease.
Συγγραφείς:
Georgaki-Angelaki, Helen
Lycopoulou, Lilia
Stergiou, Nicolaos
and Lazopoulou, Despina
Paraskevakou, Helen
Giannaki-Psinaki,
Maria
Mentis, Andreas
Περιοδικό:
Pediatric Nephrology
Λέξεις-κλειδιά:
CMV-PCR; Cytomegalovirus; Ganciclovir; Membranous nephritis; Renal
biopsy
DOI:
10.1007/s00467-008-0966-z
