Τίτλος:
Elevated soluble intercellular adhesion molecule-1 levels are associated
with poor short-term prognosis in middle-aged patients with acute
ischaemic stroke
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
Background: There is increasing evidence that cellular adhesion
molecules (CAMs) play an important role in the pathophysiology of acute
ischaemic stroke. We examined the prognostic value of soluble
intercellular adhesion molecule-1 (sICAM-1) and soluble vascular cell
adhesion molecule-1 (sVCAM-1) on in-hospital mortality in patients with
ischaemic stroke.
Methods: We recruited 241 consecutive patients <= 65 years of age who
were admitted with acute ischaemic stroke. Serum levels of sICAM-1 and
sVCAM-1 were determined within 12 h from admission. Seventy-six subjects
without evidence of cardiovascular disease, matched for age and sex,
served as controls.
Results: Patients with acute ischaemic stroke had higher sICAM levels
compared to controls [ 267 (220-325) versus 200 (179-225) ng/ml,
pb0.001]. Sixteen (6.6%) patients died during hospitalization. sICAM-1
and sVCAM-1 levels were significantly higher in patients who died
compared to those who survived [ 370 (324-453) versus 260 (219-313)
ng/ml, pb0.001 and 790 (495-985) versus 576 (494-671) ng/ml, p=0.01,
respectively] but only sICAM-1 levels were independently associated with
early death, after adjusting for various confounding factors. For 10
ng/ml increase in sICAM-1 levels there was a 9% higher risk of dying.
Cut-off point analysis revealed that sICAM-1 levels >322 ng/ml were the
optimal points that discriminated those who died from the rest of the
patients.
Conclusions: High sICAM-1 levels on admission are associated with early
death in ischaemic middle-aged stroke patients suggesting a pathogenetic
role of inflammation in the evolution of ischaemic stroke. (C) 2007
Elsevier Ireland Ltd. All rights reserved.
Συγγραφείς:
Rallidis, Loukianos S.
Zolindaki, Maria G.
Vikelis, Michalis and
Kaliva, Katerina
Papadopoulos, Costas
Kremastinos, Dimitrios Th.
Περιοδικό:
International Journal of Cardiology
Εκδότης:
Elsevier Ireland Ltd
Λέξεις-κλειδιά:
Soluble intercellular adhesion molecule-1; Soluble vascular cell
adhesion molecule-1; In-hospital mortality; Ischaemic stroke
DOI:
10.1016/j.ijcard.2007.11.031
