Τίτλος:
The Association between Diet and Serum Concentrations of IGF-I, IGFBP-1,
IGFBP-2, and IGFBP-3 in the European Prospective Investigation into
Cancer and Nutrition
Περίληψη:
Circulating concentrations of insulin-like growth factor I (IGF-I) and
IGF binding proteins (IGFBP) have been associated with the risk of
several types of cancer. Dietary correlates of IGF-I and IGFBPs are not
yet well established. The objective of this study was to assess the
association between dietary intake and serum concentrations of IGF-I,
IGFBP-1, IGFBP-2, and IGFBP-3 in a cross-sectional analysis of 4,731 men
and women taking part in the European Prospective Investigation into
Cancer and Nutrition. Diet was assessed using country-specific validated
dietary questionnaires. Serum concentrations of IGF-I, IGFBP-1, IGFBP-2
and IGFBP-3 were measured, and the associations between diet and IGF-I
and IGFBPs were assessed using multiple linear regression adjusting for
sex, age, body mass index, smoking status, and alcohol and energy
intake. Each I SD increment increase in total and dairy protein and
calcium intake was associated with an increase in IGF-I concentration of
2.5%, 2.4%, and 3.3%, respectively (P for trend <0.001 for all) and a
decrease in IGFBP-2 of 3.5%, 3.5%, and 5.4% (P for trend <0.001 for
all), respectively. There were no significant associations between the
intake of protein or calcium from nondairy sources and IGF-I. The
results from this large cross-sectional analysis show that either the
intake of dairy protein or calcium is an important dietary determinant
of IGF-I and IGFBP-2 concentrations; however, we suggest that it is more
likely to be protein from dairy products. (Cancer Epidemiol Biomarkers
Prev 2009;18(5):1333-40)
Συγγραφείς:
Crowe, Francesca L.
Key, Timothy J.
Allen, Naomi E.
Appleby,
Paul N.
Roddam, Andrew
Overvad, Kim
Gronbaek, Henning and
Tjonneland, Anne
Halkjaer, Jutte
Dossus, Laure
Boeing,
Heiner
Kroeger, Janine
Trichopoulou, Antonia
Dilis, Vardis
and Trichopoulos, Dimitrios
Boutron-Ruault, Marie-Christine
De
Lauzon, Blandine
Clavel-Chapelon, Francoise
Palli, Domenico and
Berrino, Franco
Panico, Salvatore
Tumino, Rosario
Sacerdote,
Carlotta
Bueno-de-Mesquita, H. Bas
Vrieling, Alina
van Gils,
Carla H.
Peeters, Petra H. M.
Gram, Inger T.
Skeie, Guri and
Lund, Eiliv
Rodriguez, Laudina
Jakszyn, Paula
Molina-Montes,
Esther
Tormo, Maria J.
Barricarte, Aurelio
Larranaga, Nerea
and Khaw, Kay-Tee
Bingham, Sheila
Rinaldi, Sabina
Slimani,
Nadia
Norat, Teresa
Gallo, Valentina
Riboli, Elio
Kaaks,
Rudolf
