Περίληψη:
Background Cyclin E is a protein that plays a key role in the G1 -> S
transition of the normal cell cycle. The product of retinoblastoma gene
(pRb) is the master regulator of entry into the cell cycle and p21
protein is a cyclin-dependent kinase inhibitor that disturbs the
progression through the cell cycle. The expression of these proteins,
among many others, is being deregulated in tumorogenesis. The aim of
this study was to investigate whether cyclin E, pRb, and p21 can be used
as prognostic indicators in gastric cancer. Material and Methods
Fifty-six patients with gastric adenocarcinoma, who underwent curative
resection, constituted the group of our study. The immunohistochemical
expression of cyclin E, pRb, and p21 proteins was examined and
correlated with clinical-pathological parameters and survival. Results
Positive cyclin E immunostaining was observed in 23 tumors (41.1%). It
was associated with intestinal Lauren classification (P = 0.003), nodal
infiltration (P = 0.0025), size of the tumor > 5 cm (P = 0.032), and
lymphatic (P = 0.042) and vascular invasion (P = 0.0029). Nevertheless,
the survival of patients with positive cyclin E tumors was not
significantly shorter than that of negative patients. Positive pRb
immunostaining was found in 24 (42.9%) cases and it was associated with
the absence of Helicobacter pylori (P = 0.044), whereas positive p21
immunostaining was found in 21 tumors (37.5%) and it was associated
with less depth of gastric wall infiltration (P = 0.001), the absence of
lymphatic (P = 0.019) and vascular infiltration (P = 0.024), and the
absence of liver metastasis (P = 0.044). Cyclin E expression was
associated with pRb expression (P = 0.023), but was correlated inversely
with p21 expression (P = 0.009). The survival of patients with
pRb-positive tumors and the survival of patients with p21-positive
tumors were significantly longer than that of negative patients (P =
0.0044 and P < 0.001, respectively). Conclusion The expression of cyclin
E could not predict the survival in this series of patients with gastric
cancer, whereas the expression of pRb and p21 was associated with a
favorable prognosis.
Συγγραφείς:
Kouraklis, Gregory
Katsoulis, Iraklis E.
Theocharis, Stamatios
and Tsourouflis, Gerasimos
Xipolitas, Nikos
Glinavou, Andromahi
and Sioka, Chrysa
Kostakis, Alkiviadis
