Τίτλος:
Serum Dickkopf-1 is increased and correlates with reduced bone mineral
density in patients with thalassemia-induced osteoporosis. Reduction
post-zoledronic acid administration
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
Dickkopf-1 is an inhibitor of Wnt signaling, which is crucial for
osteoblast differentiation. We evaluated serum levels of Dickkopf-1 in
66 patients with thalassemia-induced osteoporosis who received therapy
with zoledronic acid in a placebo-controlled, randomized trial. At
baseline, thalassemia patients had increased serum levels of Dickkopf-1
that correlated with reduced bone mineral density of the lumbar spine
and the distal radius. High Dickkopf-1 also correlated with increased
bone resorption and reduced bone formation markets. Zoledronic acid
produced a reduction in serum Dickkopf-1, which was associated with bone
mineral density increase after 12 months of therapy. On the contrary,
placebo group showed a borderline increase of Dickkopf-1, which was
higher in patients who showed deterioration in pain scores. These
results suggest that Dickkopf-1 is implicated in the pathogenesis of
osteoporosis in thalassemia and reveal Dickkopf-1 as a possible target
for the development of novel agents for the management of
thalassemia-induced osteoporosis (ClinicalTrials. got., Identifier:
NCT00346242).
Συγγραφείς:
Voskaridou, Ersi
Christoulas, Dimitrios
Xirakia, Charoula and
Varvagiannis, Konstantinos
Boutsikas, Georgios
Bilalis, Antonios
and Kastritis, Efstathios
Papatheodorou, Athanasios
Terpos,
Evangelos
Περιοδικό:
Haematologica-the hematology journal
Εκδότης:
Ferrata Storti Foundation
Λέξεις-κλειδιά:
thalassemia; osteoporosis; Dickkopf-1; osteoblast; zoledronic acid
DOI:
10.3324/haematol.2008.000893
