Περίληψη:
There is growing interest in the possible health threat posed by
endocrine-disrupting chemicals (EDCs), which are substances in our
environment, food, and consumer products that interfere with hormone
biosynthesis, metabolism, or action resulting in a deviation from normal
homeostatic control or reproduction. In this first Scientific Statement
of The Endocrine Society, we present the evidence that endocrine
disruptors have effects on male and female reproduction, breast
development and cancer, prostate cancer, neuroendocrinology, thyroid,
metabolism and obesity, and cardiovascular endocrinology. Results from
animal models, human clinical observations, and epidemiological studies
converge to implicate EDCs as a significant concern to public health.
The mechanisms of EDCs involve divergent pathways including (but not
limited to) estrogenic, antiandrogenic, thyroid, peroxisome
proliferator-activated receptor gamma, retinoid, and actions through
other nuclear receptors; steroidogenic enzymes; neurotransmitter
receptors and systems; and many other pathways that are highly conserved
in wildlife and humans, and which can be modeled in laboratory in vitro
and in vivo models. Furthermore, EDCs represent a broad class of
molecules such as organochlorinated pesticides and industrial chemicals,
plastics and plasticizers, fuels, and many other chemicals that are
present in the environment or are in widespread use. We make a number of
recommendations to increase understanding of effects of EDCs, including
enhancing increased basic and clinical research, invoking the
precautionary principle, and advocating involvement of individual and
scientific society stakeholders in communicating and implementing
changes in public policy and awareness. (Endocrine Reviews 30: 293-342,
2009)
Συγγραφείς:
Diamanti-Kandarakis, Evanthia
Bourguignon, Jean-Pierre
Giudice,
Linda C.
Hauser, Russ
Prins, Gail S.
Soto, Ana M. and
Zoeller, R. Thomas
Gore, Andrea C.
