Περίληψη:
Background: Increasing evidence suggests that general obesity
[measured by body mass index (BMI)] is positively associated with risk
of esophageal adenocarcinoma (EAC). In contrast, previous studies have
shown inverse relations with esophageal squamous cell carcinoma (ESCC).
However, it is still unclear whether body fat distribution, particularly
abdominal obesity, is associated with each type of esophageal cancer.
Methods: We applied multivariable adjusted Cox proportional hazards
regression to investigate the association between anthropometric
measures and risk of EAC and ESCC among 346,554 men and women
participating in the European Prospective Investigation into Cancer and
Nutrition. All statistical tests were two sided.
Results: During 8.9 years of follow-up, we documented 88 incident cases
of EAC and 110 cases of ESCC. BMI, waist circumference, and waist-to-hip
ratio (WHR) were positively associated with EAC risk [highest versus
lowest quintile; relative risk (RR), 2.60; 95% confidence interval
(95% CI), 1.23-5.51; P-trend < 0.01; RR, 3.07; 95% CI, 1.35-6.98;
P-trend < 0.003; and RR, 2.12; 95% CI, 0.98-4.57; P-trend < 0.004]. In
contrast, BMI and waist circumference were inversely related to ESCC
risk, whereas WHR showed no association with ESCC. In stratified
analyses, BMI and waist circumference were significantly inversely
related to ESCC only among smokers but not among nonsmokers. However,
when controlled for BMI, we found positive associations for waist
circumference and WHR with ESCC, and these associations were observed
among smokers and nonsmokers.
Conclusion: General and abdominal obesity were associated with higher
EAC risk. Further, our study suggests that particularly an abdominal
body fat distribution might also be a risk factor for ESCC. (Cancer
Epidemiol Biomarkers Prev 2009;18(7):2079-89)
Συγγραφείς:
Steffen, Annika
Schulze, Matthias B.
Pischon, Tobias and
Dietrich, Thomas
Molina, Esther
Chirlaque, Maria-Dolores and
Barricarte, Aurelio
Amiano, Pilar
Quiros, J. Ramon
Tumino,
Rosario
Mattiello, Amalia
Palli, Domenico
Vineis, Paolo and
Agnoli, Claudia
Misirli, Gesthimani
Boffetta, Paolo
Kaaks,
Rudolf
Rohrmann, Sabine
Bueno-de-Mesquita, H. Bas
Peeters,
Petra H. M.
May, Anne M.
Spencer, Elizabeth A.
Allen, Naomi
E.
Bingham, Sheila
Tjonneland, Anne
Halkjaer, Jytte and
Overvad, Kim
Stegger, Jakob
Manjer, Jonas
Lindkvist, Bjorn
and Hallmanns, Goran
Stenling, Roger
Lund, Eiliv
Riboli,
Elio
Gonzalez, Carlos A.
Boeing, Heiner
