Τίτλος:
Evaluation of DNA ploidy in relation with established prognostic factors
in patients with locally advanced (unresectable) or metastatic
pancreatic adenocarcinoma: a retrospective analysis
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
Background: Most patients with ductal pancreatic adenocarcinoma are
diagnosed with locally advanced (unresectable) or metastatic disease.
The aim of this study was to evaluate the prognostic significance of DNA
ploidy in relation with established clinical and laboratory variables in
such patients.
Methods: Two hundred and twenty six patients were studied
retrospectively. Twenty two potential prognostic variables
(demographics, clinical parameters, biochemical markers, treatment
modality) were examined.
Results: Mean survival time was 38.41 weeks (95% c.i.: 33.17-43.65),
median survival 27.00 weeks (95% c.i.: 23.18-30.82). On multivariate
analysis, 10 factors had an independent effect on survival: performance
status, local extension of tumor, distant metastases, ploidy score,
anemia under epoetin therapy, weight loss, pain, steatorrhoea, CEA, and
palliative surgery and chemotherapy. Patients managed with palliative
surgery and chemotherapy had 6.7 times lower probability of death in
comparison with patients without any treatment. Patients with ploidy
score > 3.6 had 5.0 times higher probability of death in comparison with
patients with ploidy score < 2.2 and these with ploidy score 2.2-3.6 had
6.3 times higher probability of death in comparison with patients with
ploidy score < 2.2.
Conclusion: According to the significance of the examined factor,
survival was improved mainly by the combination of surgery and
chemotherapy, and the presence of low DNA ploidy score.
Συγγραφείς:
Tsavaris, Nikolas
Kavantzas, Nicolaos
Tsigritis, Kostantinos and
Xynos, Ioannis D.
Papadoniou, Nikitas
Lazaris, Andreas and
Kosmas, Christos
Agrogiannis, George
Dokou, Anna
Felekouras,
Evangelos
Antoniou, Efstathios
Polyzos, Aris
Sarantonis,
John
Tsipras, Heracles
Karatzas, Gavrilos
Papalambros,
Alexandros
Patsouris, Efstratios S.
DOI:
10.1186/1471-2407-9-264
