Περίληψη:
We conducted a two-stage genome-wide association study of pancreatic
cancer, a cancer with one of the lowest survival rates worldwide. We
genotyped 558,542 SNPs in 1,896 individuals with pancreatic cancer and
1,939 controls drawn from 12 prospective cohorts plus one hospital-based
case-control study. We conducted a combined analysis of these groups
plus an additional 2,457 affected individuals and 2,654 controls from
eight case-control studies, adjusting for study, sex, ancestry and five
principal components. We identified an association between a locus on
9q34 and pancreatic cancer marked by the SNP rs505922 (combined P = 5.37
x 10(-8); multiplicative per-allele odds ratio 1.20; 95% confidence
interval 1.12-1.28). This SNP maps to the first intron of the ABO blood
group gene. Our results are consistent with earlier epidemiologic
evidence suggesting that people with blood group O may have a lower risk
of pancreatic cancer than those with groups A or B.
Συγγραφείς:
Amundadottir, Laufey
Kraft, Peter
Stolzenberg-Solomon, Rachael
Z.
Fuchs, Charles S.
Petersen, Gloria M.
Arslan, Alan A. and
Bueno-de-Mesquita, H. Bas
Gross, Myron
Helzlsouer, Kathy and
Jacobs, Eric J.
LaCroix, Andrea
Zheng, Wei
Albanes,
Demetrius
Bamlet, William
Berg, Christine D.
Berrino, Franco
and Bingham, Sheila
Buring, Julie E.
Bracci, Paige M. and
Canzian, Federico
Clavel-Chapelon, Francoise
Clipp, Sandra and
Cotterchio, Michelle
de Andrade, Mariza
Duell, Eric J.
Fox,
Jr., John W.
Gallinger, Steven
Gaziano, J. Michael and
Giovannucci, Edward L.
Goggins, Michael
Gonzalez, Carlos A. and
Hallmans, Goran
Hankinson, Susan E.
Hassan, Manal
Holly,
Elizabeth A.
Hunter, David J.
Hutchinson, Amy
Jackson,
Rebecca
Jacobs, Kevin B.
Jenab, Mazda
Kaaks, Rudolf and
Klein, Alison P.
Kooperberg, Charles
Kurtz, Robert C.
Li,
Donghui
Lynch, Shannon M.
Mandelson, Margaret
McWilliams,
Robert R.
Mendelsohn, Julie B.
Michaud, Dominique S.
Olson,
Sara H.
Overvad, Kim
Patel, Alpa V.
Peeters, Petra H. M. and
Rajkovic, Aleksandar
Riboli, Elio
Risch, Harvey A.
Shu,
Xiao-Ou
Thomas, Gilles
Tobias, Geoffrey S.
Trichopoulos,
Dimitrios
Van Den Eeden, Stephen K.
Virtamo, Jarmo and
Wactawski-Wende, Jean
Wolpin, Brian M.
Yu, Herbert
Yu, Kai
and Zeleniuch-Jacquotte, Anne
Chanock, Stephen J.
Hartge,
Patricia
Hoover, Robert N.
