Περίληψη:
Aim: Although Stenotrophomonas maltophilia is commonly isolated from
clinical specimens, mainly of immunocompromised patients, mortality
directly attributable to this organism is controversial. We searched
PubMed, Scopus and Cochrane and assessed the available literature
regarding mortality attributable to infection with S, maltophilia.
Method: Crude mortality and mortality of case patients receiving
appropriate or inappropriate initial antibiotic treatment were
evaluated. A total of 15 articles (six matched case-control, seven
case-control and two controlled cohort studies) were identified; 13
studies (the six matched case-control and the seven case-control
studies) were included in the analysis. Results: In seven studies,
mortality of cases differed significantly from that of controls.
Mortality was significantly higher in cases than controls in six of
these studies; it was lower in cases than controls in the one study
where controls had Pseudomonas aeruginosa bacteremia. In six studies,
mortality of cases did not differ significantly compared with the
respective controls. In three of four studies providing relevant data,
mortality of cases treated with inappropriate initial antibiotic
treatment was significantly higher compared with cases treated with
appropriate initial antibiotic treatment. Conclusion: A considerable
mortality rate (up to 37.5%) can be attributed to S. maltophilia
infection. Thus, clinicians should not underestimate the clinical
significance of S. maltophilia infections.
Συγγραφείς:
Falagas, Matthew E.
Kastoris, Antonia C.
Vouloumanou, Evridiki
K.
Rafailidis, Petros I.
Kapaskelis, Anastasios M. and
Dimopoulos, George
