Τίτλος:
Treatment of Sperm With Platelet-activating Factor Does Not Improve
Intrauterine Insemination Outcome in Unselected Cases of Mild Male
Factor Infertility: A Prospective Double-blind Randomized Crossover
Study
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
OBJECTIVES To evaluate the effect of sperm treatment with exogenous
platelet-activating factor (PAF) on intrauterine insemination (IUI)
clinical pregnancy rate in cases of mild male factor infertility. PAF is
a phospholipid mediator, which is present in human sperm.
METHODS The study was performed in the Assisted Reproduction Unit of the
2nd Department of Obstetrics and Gynecology, University of Athens,
Aretaieion Hospital, Athens, Greece, and included 92 couples who
presented with mild male factor infertility-all candidates for IUI. A
maximum of 4 IUI cycles per couple with or without exogenous PAF
treatment were performed and the main outcome measure was the clinical
pregnancy rate (pregnancies confirmed by ultrasonography per 100
cycles).
RESULTS The overall clinical pregnancy rate after a maximum of 4 IUI
cycles was comparable in cases with and without sperm treatment with PAF
(12.24% vs 11-11%). Addition or exclusion of PAF sperm treatment in
the same patients did not significantly alter the outcome.
CONCLUSIONS The generalized use of exogenous PAF for the preparation of
sperm in unselected cases of mild male infertility does not improve the
clinical outcome of IUI. UROLCGY 74: 1025-1028, 2009. (C) 2009 Elsevier
Inc.
Συγγραφείς:
Baka, Stavroula
Grigoriou, Odysseas
Hassiakos, Dirnitris and
Konidaris, Socrates
Papadias, Konstantinos
Makrakis, Evangelos
Περιοδικό:
European urology oncology
Εκδότης:
EXCERPTA MEDICA INC-ELSEVIER SCIENCE INC
DOI:
10.1016/j.urology.2009.06.023
