Ερευνητικό υλικό ΕΚΠΑ

Early alterations of the innate and adaptive immune statuses in sepsis
according to the type of underlying infection

Αγγλικά

Introduction: Although major changes of the immune system have been
described in sepsis, it has never been studied whether these may differ
in relation to the type of underlying infection or not. This was studied
for the first time.
Methods: The statuses of the innate and adaptive immune systems were
prospectively compared in 505 patients. Whole blood was sampled within
less than 24 hours of advent of sepsis; white blood cells were stained
with monoclonal antibodies and analyzed though a flow cytometer.
Results: Expression of HLA-DR was significantly decreased among patients
with severe sepsis/shock due to acute pyelonephritis and intraabdominal
infections compared with sepsis. The rate of apoptosis of natural killer
(NK) cells differed significantly among patients with severe
sepsis/shock due to ventilator-associated pneumonia (VAP) and
hospital-acquired pneumonia (HAP) compared with sepsis. The rate of
apoptosis of NKT cells differed significantly among patients with severe
sepsis/shock due to acute pyelonephritis, primary bacteremia and VAP/HAP
compared with sepsis. Regarding adaptive immunity, absolute counts of
CD4-lymphocytes were significantly decreased among patients with severe
sepsis/shock due to community-acquired pneumonia (CAP) and
intraabdominal infections compared with sepsis. Absolute counts of
B-lymphocytes were significantly decreased among patients with severe
sepsis/shock due to CAP compared with sepsis.
Conclusions: Major differences of the early statuses of the innate and
adaptive immune systems exist between sepsis and severe sepsis/shock in
relation to the underlying type of infection. These results may have a
major impact on therapeutics.

2010

Gogos, Charalambos
Kotsaki, Antigone
Pelekanou, Aimilia and
Giannikopoulos, George
Vaki, Ilia
Maravitsa, Panagiota and
Adamis, Stephanos
Alexiou, Zoi
Andrianopoulos, George and
Antonopoulou, Anastasia
Athanassia, Sofia
Baziaka, Fotini and
Charalambous, Aikaterini
Christodoulou, Sofia
Dimopoulou, Ioanna
and Floros, Ioannis
Giannitsioti, Efthymia
Gkanas, Panagiotis
and Ioakeimidou, Aikaterini
Kanellakopoulou, Kyriaki
Karabela,
Niki
Karagianni, Vassiliki
Katsarolis, Ioannis
Kontopithari,
Georgia
Kopterides, Petros
Koutelidakis, Ioannis
Koutoukas,
Pantelis
Kranidioti, Hariklia
Lignos, Michalis
Louis,
Konstantinos
Lymberopoulou, Korina
Mainas, Efstratios and
Marioli, Androniki
Massouras, Charalambos
Mavrou, Irini and
Mpalla, Margarita
Michalia, Martha
Mylona, Heleni
Mytas,
Vassilios
Papanikolaou, Ilias
Papanikolaou, Konstantinos and
Patrani, Maria
Perdios, Ioannis
Plachouras, Diamantis and
Pistiki, Aikaterini
Protopapas, Konstantinos
Rigaki, Kalliopi
and Sakka, Vissaria
Sartzi, Monika
Skouras, Vassilios
Souli,
Maria
Spyridaki, Aikaterini
Strouvalis, Ioannis
Tsaganos,
Thomas
Zografos, George
Mandragos, Konstantinos and
Klouva-Molyvdas, Phylis
Maggina, Nina
Giamarellou, Helen and
Armaganidis, Apostolos
Giamarellos-Bourboulis, Evangelos J.

Critical Care and Resuscitation

BioMed Central Ltd.

14

3

https://doi.org/10.1186/cc9031

10.1186/cc9031

https://pergamos.lib.uoa.gr/uoa/dl/object/3144382