Περίληψη:
Background: Matrix metalloproteinases (MMPs) have been implicated in the
escalation of fibrosis and remodeling which are central to the
subsequent progression of a parapneumonic pleural effusion to empyema.
Objectives: The aim of this study was the assessment of MMP-2, MMP-8 and
MMP-9 in parapneumonic pleural effusions in order to examine their value
in the differentiation between uncomplicated and complicated
parapneumonic effusions. Methods: The study included 208 consecutive
patients with pleural effusions [60 parapneumonic (27 uncomplicated
parapneumonic, 17 complicated parapneumonic, 16 empyemas), 24
tuberculous, 89 malignant and 35 transudates]. Concentrations of pleural
fluid and serum MMP-2, MMP-8 and MMP-9 were determined by immunoassay.
Results: Pleural fluid MMP-8 and MMP-9 levels were higher in complicated
parapneumonic effusions or empyema than in uncomplicated effusions,
while their serum levels were higher in complicated par apneumonic
effusions. MMP-2 levels were higher in uncomplicated than in complicated
parapneumonic effusions or empyema. Pleural fluid MMP-2/MMP-9 ratio was
the best marker to differentiate complicated from uncomplicated
parapneumonic effusions, with a sensitivity of 94.1% and a specificity
of 77.8% at a cut-off point of 1.32 (AUC = 0.887). Conclusions: Pleural
fluid MMP-2, MMP-8 and MMP-9 may provide useful information for
differentiating between uncomplicated and complicated parapneumonic
effusions. Copyright (C) 2010 S. Karger AG, Basel
Συγγραφείς:
Oikonomidi, Smaragda
Kostikas, Konstantinos
Kalomenidis, Ioannis
and Tsilioni, Irene
Daenas, Christos
Gourgoulianis, Konstantinos
I.
Kiropoulos, Theodoros S.
