Περίληψη:
Background Metabolic syndrome (MetS) is common and is associated with
increased cardiovascular morbidity and mortality. Recent prospective
studies suggested that MetS is associated with increased risk of heart
failure. In the present cross-sectional study, we examined the
association between left ventricular myocardial performance with MetS.
Materials and Methods A total of 550 non-diabetic subjects, 275 without
MetS and 275 with MetS, matched for gender, age and body mass index and
free of clinically apparent macrovascular disease were studied. MetS was
diagnosed using the NCEP-ATP III criteria. Left ventricular myocardial
performance was assessed using the Tei index.
Results Both men and women with MetS had higher values of the Tei index,
indicating worse myocardial performance, in comparison with those
without MetS (p < 0.001). Participants with a cluster of more components
of the MetS had higher Tei index values than those with fewer components
of the MetS. In addition, among normotensive subjects, those with MetS
had significantly higher Tei index values than subjects without MetS.
Multivariate linear regression analysis, after adjustment for age and
body mass index, demonstrated that MetS status and from the individual
components of the MetS, high fasting blood glucose levels, higher blood
pressure, low high density lipoprotein levels and high waist
circumference were associated with worse myocardial performance.
Conclusion MetS is associated with subclinical myocardial dysfunction in
both men and women. Strategies to reduce the cardiovascular burden and
the risk of heart failure associated with MetS should aim at prevention
of the MetS and its related conditions. Copyright (C) 2010 John Wiley &
Sons, Ltd.
Συγγραφείς:
Voulgari, Christina
Moyssakis, Ioannis
Papazafiropoulou,
Athanasia
Perrea, Despoina
Kyriaki, Despoina
Katsilambros,
Nicholas
Tentolouris, Nicholas
