Περίληψη:
Introduction: In the European Union, there are 180,000 new cases of
upper aerodigestive tract (UADT) cancer cases per year - more than half
of whom will die of the disease. Socioeconomic inequalities in UADT
cancer incidence are recognised across Europe. We aimed to assess the
components of socioeconomic risk both independently and through their
influence on the known behavioural risk factors of smoking, alcohol
consumption and diet.
Patients and methods: A multicentre case-control study with 2198 cases
of UADT cancer and 2141 controls from hospital and population sources
was undertaken involving 14 centres from 10 countries. Personal
interviews collected information on demographics, lifetime occupation
history, smoking, alcohol consumption and diet. Socioeconomic status was
measured by education, occupational social class and Unemployment. Odds
ratios (ORs) and 95% confidence intervals (CIs) were computed using
Unconditional logistic regression.
Results: When controlling for age, sex and centre significantly
increased risks for UADT cancer were observed for those with low versus
high educational attainment OR = 1.98 (95% CI 1.67, 2.36). Similarly,
for occupational socioeconomic indicators - comparing the lowest versus
highest International Socio-Economic index (ISEI) quartile for the
longest occupation gave OR = 1.60 (1.28, 2.00); and for unemployment OR
= 1.64 (1.24, 2.17). Statistical significance remained for low education
when adjusting for smoking, alcohol and diet behaviours OR = 1.29 (1.06,
1.57) in the multivariate analysis. Inequalities were observed only
among men but not among women and were greater among those in the
British Isles and Eastern European countries than in Southern and
Central/Northern European countries, Associations were broadly
consistent for subsite and source of controls (hospital and community).
Conclusion: Socioeconomic inequalities for UADT cancers are only
observed among men and are not totally explained by smoking, alcohol
drinking and diet. (C) 2009 Elsevier Ltd. All rights reserved.
Συγγραφείς:
Conway, D. I.
McKinney, P. A.
McMahon, A. D.
Ahrens, W. and
Schmeisser, N.
Benhamou, S.
Bouchardy, C.
Macfarlane, G. J.
and Macfarlane, T. V.
Lagiou, P.
Minaki, P.
Bencko, V. and
Holcatova, I.
Merletti, F.
Richiardi, L.
Kjaerheim, K. and
Agudo, A.
Castellsague, X.
Talamini, R.
Barzan, L. and
Canova, C.
Simonato, L.
Lowry, R. J.
Znaor, A.
Healy, C.
M.
McCartan, B. E.
Marron, M.
Hashibe, M.
Brennan, P.
