Τίτλος:
Effects of Antimicrobial Prophylaxis on Asymptomatic Bacteriuria and
Predictors of Failure in Patients with Multiple Sclerosis
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
We studied the effects of antimicrobial prophylaxis and possible
predictors of failure in multiple sclerosis patients with bacteriuria
and bladder dysfunction. Patients were categorized into 3 groups,
according to post-voided residual urine volume (PVR): patients with
indications for self-intermittent catheterization (SIC) who elected
(Group A, n=39) or not (Group B, n=53) to use SIC and patients with no
indication for SIC (Group C, n=75). In group A, 90% of patients
developed bacteriuria after SIC. Rates of bacteriuria in groups B and C
were significantly lower (34% and 24%, respectively, all p<0.001).
Prophylaxis failed in 31% and 22% of patients in groups A and B,
respectively whereas all group C patients responded to prophylaxis.
Symptomatic urinary tract infection was observed only in 14% of group A
patients. Significant predictors of prophylaxis failure were an expanded
disability status scale (EDSS) score >= 6 (p.0.05), a high PVR (p <=
0.075) and resistance to prophylaxis regimen (p <= 0.007). SIC did not
have a significant association with prophylaxis failure. In multivariate
analysis only a higher EDSS score ( 6) predicted prophylaxis failure
(p=0.019).
Συγγραφείς:
Fakas, N.
Souli, M.
Koratzanis, G.
Karageorgiou, C. and
Giamarellou, H.
Kanellakopoulou, K.
Περιοδικό:
Journal of Chemotherapy
Εκδότης:
TAYLOR & FRANCIS LTD LONDON
Λέξεις-κλειδιά:
urinary tract infection; self-intermittent catheterization; antibiotic
prophylaxis; expanded disability status scale; norfloxacin;
nitrofurantoin
DOI:
10.1179/joc.2010.22.1.36
