Τίτλος:
Beta-adrenergic receptor blockade and prostate peptide growth factor
expression in the rat
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
Results: At sacrifice, body weight as well as ventral prostate weight
and prostate morphology were not significantly affected by propranolol
treatment. Stromal elements and the majority of prostatic epithelial
cells in control animals demonstrated positive staining for the
anti-bFGF antibody, while positive staining for TGF beta was seen only
in epithelial cells. Propranolol treatment resulted in considerable
decrease of bFGF staining intensity in both stromal and epithelial
cells, while the immunostaining pattern for TGF beta was almost
abolished.
Results and Conclusions: The results from this study provide evidence to
suggest that prolonged propranolol treatment affects peptide growth
expression in the rat ventral prostate as in other tissues, and confirms
the notion that autonomic nervous system controls, at least partly,
prostate gland functional characteristics. Moreover, it may also affect
prostate homeostasis by intervening in stromal-epithelial interaction
through alterations in the expression of peptide growth factors without
affecting prostate volume.
Συγγραφείς:
Mitropoulos, Dionisios
Kyroudi-Voulgari, Aspasia
Stratigea,
Filia
Perea, Despina
Boudoulas, Harisios
Karayannacos,
Panayotis
Περιοδικό:
Immunopharmacology and Immunotoxicology
Εκδότης:
TAYLOR & FRANCIS LTD LONDON
Λέξεις-κλειδιά:
beta-adrenoreceptor antagonists; peptide growth factors; rat; prostate;
propranolol
DOI:
10.3109/08923970903164326
