Τίτλος:
Comparative antilipidemic effect of N-acetylcysteine and sesame oil
administration in diet-induced hypercholesterolemic mice
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
Background: There is an increasing number of novel antilipidemic
therapies under consideration. The putative hypolipidemic effect of
N-acetylcysteine (NAC) and sesame oil was studied in a mouse model of
dietary-induced hypercholesterolemia.
Methods: Male C57bl/6 mice were assigned to the following groups: (NC)
control group, (HC) group receiving test diet supplemented with 2%
cholesterol and 0.5% cholic acid for 8 weeks, (HCN) group receiving the
test diet with NAC supplementation (230 mg/kg p.o.) and (HCS) group fed
the test diet enriched with 10% sesame oil. Total serum cholesterol,
LDL-cholesterol, HDL-cholesterol and triglycerides were assayed at the
beginning and at the end of the experiment. Total peroxides and nitric
oxide (NO) levels were measured in the serum at the end of the
experiment. Hepatic and aortic lesions were evaluated by
haematoxylin-eosin staining.
Results: Higher serum levels of total and LDL-cholesterol were recorded
in all groups fed the high cholesterol diet. The HCN group presented
reduced lipid levels compared to HC and HCS groups. No differences were
observed between HCS and HC groups. Peroxide content in serum was
markedly increased in mice consuming high cholesterol diet. NAC and
sesame oil administration led to a significant decrease of serum lipid
peroxidation in the levels of control group, whereas only NAC restored
NO bioavailability. In terms of liver histology, the lesions observed in
HCN group were less severe than those seen in the other high cholesterol
groups.
Conclusion: Co-administration of NAC, but not sesame oil, restored the
disturbed lipid profile and improved hepatic steatosis in the studied
diet-induced hypercholesterolemic mice. Both agents appear to ameliorate
serum antioxidant defense.
Συγγραφείς:
Korou, Laskarina-Maria
Agrogiannis, George
Pantopoulou, Alkisti
and Vlachos, Ioannis S.
Iliopoulos, Dimitrios
Karatzas,
Theodoros
Perrea, Despoina N.
Περιοδικό:
Lipids in Health and Disease
Εκδότης:
BioMed Central Ltd.
DOI:
10.1186/1476-511X-9-23
