Περίληψη:
Several prospective studies have shown a moderate positive association
between increasing circulating insulin-like growth factor-I (IGF-I)
levels and colorectal cancer risk. However, the associations were often
statistically nonsignificant, and the relationship of cancer risk with
IGF-I’s major binding protein, IGFBP-3, showed major discrepancies
between studies. We investigated the association of colorectal cancer
risk with serum IGF-I, total and intact IGFBP-3, in a case-control study
nested within the EPIC cohort (1,121 cases of colorectal cancer and
1,121 matched controls). Conditional logistic regression was used to
adjust for possible confounders. Our present study results were combined
in a meta-analysis with those from 9 previous prospective studies to
examine the overall evidence for a relationship of prediagnostic serum
IGF-I with colorectal cancer risk. In the EPIC study, serum
concentrations of IGF-I and IGFBP-3 showed no associations with risk of
colorectal cancer overall. Only in subgroup analyses did our study show
moderate positive associations of IGF-I levels with risk, either among
younger participants only (and only for colon cancer) or among
participants whose milk intakes were in the lowest tertile of the
population distribution (RR for an increase of 100 ng/ml = 1.43 [95%
CI = 1.13-1.93]). Nevertheless, in the meta-analysis a modest positive
association remained between serum IGF-I and colorectal cancer risk
overall (RR = 1.07 [1.01-1.14] for 1 standard deviation increase in
IGF-I). Overall, data from our present study and previous prospective
studies combined indicate a relatively modest association of colorectal
cancer risk with serum IGF-I.
Συγγραφείς:
Rinaldi, Sabina
Cleveland, Rebecca
Norat, Teresa
Biessy,
Carine
Rohrmann, Sabine
Linseisen, Jakob
Boeing, Heiner and
Pischon, Tobias
Panico, Salvatore
Agnoli, Claudia
Palli,
Domenico
Tumino, Rosario
Vineis, Paolo
Peeters, Petra H. M.
and van Gils, Carla H.
Bueno-de-Mesquita, Bas H.
Vrieling, Alina
and Allen, Naomi E.
Roddam, Andrew
Bingham, Sheila
Khaw,
Kay-Tee
Manjer, Jonas
Borgquist, Signe
Dumeaux, Vanessa and
Gram, Inger Torhild
Lund, Eiliv
Trichopoulou, Antonia and
Makrygiannis, Georgios
Benetou, Vassiliki
Molina, Esther and
Donate Suarez, Ignacio
Barricarte Gurrea, Aurelio
Gonzalez,
Carlos A.
Tormo, Maria-Jose
Altzibar, Jone M.
Olsen, Anja
and Tjonneland, Anne
Gronbaek, Henning
Overvad, Kim and
Clavel-Chapelon, Francoise
Boutron-Ruault, Marie-Christine and
Morois, Sophie
Slimani, Nadia
Boffetta, Paolo
Jenab, Mazda
and Riboli, Elio
Kaaks, Rudolf
