Τίτλος:
Corticotropin-releasing hormone, stress and human reproduction: an
update
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
The stress system has suppressive effects on female and male
reproductive function. Corticotrophin-releasing hormone (CRH), the
principal regulator of stress, has been identified in the female and
male reproductive system. Reproductive CRH participates in various
reproductive functions that have an inflammatory component, where it
serves as an autocrine and paracrine modulator. These include ovarian
and endometrial CRH, which may participate in the regulation of
steroidogenesis and the inflammatory processes of the ovary (ovulation
and luteolysis) and the endometrium (decidualization and blastocyst
implantation) and placental CRH, which is secreted mostly during the
latter half of pregnancy and is responsible for the onset of labor. It
has been suggested that there is a “CRH placental clock” which
determines the length of gestation and the timing of parturition and
delivery. The potential use of CRH-antagonists is presently under
intense investigation. CRH-R1 antagonists have been used in animal
studies to elucidate the role of CRH in blastocyst implantation and
invasion, early fetal immunotolerance and premature labor. The present
review article focuses on the potential roles of CRH on the physiology
and pathophysiology of reproduction and highlights its participation in
crucial steps of pregnancy, such as implantation, fetal immune
tolerance, parturition and fetal programming of the
hypothalamic-pituitary-adrenal (HPA) axis. (C) 2010 Elsevier Ireland
Ltd. All rights reserved.
Συγγραφείς:
Kalantaridou, S. N.
Zoumakis, E.
Makrigiannakis, A. and
Lavasidis, L. G.
Vrekoussis, T.
Chrousos, G. P.
Περιοδικό:
Journal of Reproductive Immunology
Εκδότης:
Elsevier Ireland Ltd
Λέξεις-κλειδιά:
Corticotropin-releasing hormone (CRH); Fetal immunotolerance; Fetal
programming; Implantation; Parturition; Pregnancy; Preterm delivery;
Stress
DOI:
10.1016/j.jri.2010.02.005
