Περίληψη:
Background: Obesity has been proposed as a risk factor for pancreatic
cancer.
Methods: Pooled data were analyzed from the National Cancer Institute
Pancreatic Cancer Cohort Consortium (PanScan) to study the association,
between prediagnostic anthropometric measures and risk of pancreatic
cancer. PanScan applied a nested case-control study design and included
2170 cases and 2209 control subjects. Odds ratios (ORs) and 95%
confidence intervals (CIs) were estimated using unconditional logistic
regression for cohort-specific quartiles of body mass index (BMI
[calculated as weight in kilograms divided by height in meters
squared]), weight, height, waist circumference, and waist to hip ratio
as well as conventional BMI categories (underweight, <18.5; normal
weight, 18.5-24.9; overweight, 25.0-29.9; obese, 30.0-34.9; and severely
obese, >= 35.0). Models were adjusted for potential confounders.
Results: In all of the participants, a positive association between
increasing BMI and risk of pancreatic cancer was observed (adjusted OR
for the highest vs lowest BMI guartile, 1.33; 95% Cl, 1.12-1.58;
P-trend<.001). In men, the adjusted OR for pancreatic cancer for the
highest vs lowest quartile of BMI was 1.33 (95% Cl, 1.04-1.69;
P-trend<.03), and in women it was 1.34 (95% Cl, 1.05-1.70;
P-trend=.01). Increased waist to hip ratio was associated with increased
risk of pancreatic cancer in women (adjusted OR for the highest vs
lowest quartile, 1.87; 95% Cl, 1.31-2.69; P-trend=.003) but less so in
men.
Conclusions: These findings provide strong support for a positive
association between BMI and pancreatic cancer risk. In addition,
centralized fat distribution may increase pancreatic cancer risk,
especially in women. Arch Intern Med. 2010;170(9):791 -802
Συγγραφείς:
Arslan, Alan A.
Helzlsouer, Kathy J.
Kooperberg, Charles and
Shu, Xiao-Ou
Steplowski, Emily
Bueno-de-Mesquita, H. Bas and
Fuchs, Charles S.
Gross, Myron D.
Jacobs, Eric J.
LaCroix,
Andrea Z.
Petersen, Gloria M.
Stolzenberg-Solomon, Rachael Z.
and Zheng, Wei
Albanes, Demetrius
Amundadottir, Laufey and
Bamlet, William R.
Barricarte, Aurelio
Bingham, Sheila A. and
Boeing, Heiner
Boutron-Ruault, Marie-Christine
Buring, Julie E.
and Chanock, Stephen J.
Clipp, Sandra
Gaziano, J. Michael and
Giovannucci, Edward L.
Hankinson, Susan E.
Hartge, Patricia and
Hoover, Robert N.
Hunter, David J.
Hutchinson, Amy
Jacobs,
Kevin B.
Kraft, Peter
Lynch, Shannon M.
Manjer, Jonas and
Manson, JoAnn E.
McTiernan, Anne
McWilliams, Robert R. and
Mendelsohn, Julie B.
Michaud, Dominique S.
Palli, Domenico and
Rohan, Thomas E.
Slimani, Nadia
Thomas, Gilles
Tjonneland,
Anne
Tobias, Geoffrey S.
Trichopoulos, Ditnitrios
Virtamo,
Jarmo
Wolpin, Brian M.
Yu, Kai
Zeleniuch-Jacquotte, Anne and
Patel, Alpa V.
