Τίτλος:
Acute hyperhomocysteinaemia blunts endothelial dependent and endothelial
independent vasodilatation in diabetic patients
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
The aim of this study was to investigate the effects of acute,
methionine-induced hyperhomocysteinaemia on endothelial function of skin
microcirculation in diabetic compared with non-diabetic persons.
Endothelial-and non-endothelial-dependent vasodilatation of the skin
microcirculation were evaluated in 20 persons with type 2 diabetes
(59.95 +/- 2.36 years old) and 24 age-and gender-matched controls using
laser Doppler flowmetry, during fasting and four hours after 0.1 g/kg
methionine-induced acute hyperhomocysteinaemia. Methionine loading
caused a comparable increase of homocysteine in the two groups. Four
hours after induction of acute hyperhomocysteinaemia,
endothelial-dependent vasodilatation (acetylcholine effect) was lower in
the diabetic patients compared with the controls ([mean +/- SEM] 8.09
+/- 1.18-fold increase in diabetic patients vs. 11.11 +/- 1.33-fold
increase in controls, p=0.027). The same was observed for the
endothelial-independent vasodilatation (sodium-nitroprusside effect,
7.55 +/- 0.80-fold increase in the diabetic patients vs. 12.19 +/-
1.26-fold increase in controls, p=0.008). Acute hyperhomocysteinaemia
causes a decreased response of both endothelial-dependent and
endothelial-independent vasodilatation of the skin microcirculation in
diabetic compared with non-diabetic persons. These alterations might
contribute to the vascular complications of hyperhomocysteinaemia in
diabetes, and especially the microvascular ones.
Συγγραφείς:
Chousos, Ilias
Perrea, Despoina
Kyriaki, Despoina
Liatis,
Stavros
Katsilambros, Nicholas
Makrilakis, Konstantinos
Περιοδικό:
Diabetes and Vascular Disease Research
Εκδότης:
SAGE Publications Ltd
Λέξεις-κλειδιά:
diabetes mellitus type 2; endothelial function; hyperhomocysteinaemia;
iontophoresis; laser Doppler flowmetry; skin microcirculation
DOI:
10.1177/1479164110369687
